OP17 Protein intakes and risk of inflammatory bowel disease in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC-IBD)
C. Dong1, Y. Mahamat-Saleh2, A. Racine3, P. Jantchou4, S. Chan6, A. Hart5, F. Carbonnel3, M.C. Boutron-Ruault2
1Gastroenterology Department, Kremlin Bicetre Hospital, AP-HP, University Paris Sud, Saint-Mandé, France, 2Gustave Roussy Institute, Inserm, Villejuif, France, 3Gastroenterology Department, Kremlin Bicetre Hospital, AP-HP, University Paris Sud, Paris, France, 4Pediatric Department, University of Montreal, Montreal, Canada, 5Gastroenterology Department, Norwich Medical School, Norwich, UK, 6Gastroenterology and Gut Biology Department, Norwich Medical School, Norwich, UK
Background
Diet may contribute to inflammatory bowel disease (IBD) pathogenesis. In a previous French cohort, we found an association between high protein intake and increased risk of IBD. We aimed to investigate this relationship in the EPIC-IBD (European Prospective Investigation into Cancer and Nutrition – Inflammatory Bowel Diseases) cohort.
Methods
413 593 participants from 8 European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Mean daily intake of nutrients was assessed using the EPIC nutrient database. To reduce bias in the estimation of relative risks, calibrated dietary data were obtained from the country and sex-specific calibration models for all participants. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models.
Results
After a mean follow-up of 16 years, 595 incident cases of IBD were identified, including 177 Crohn’s disease (CD) and 418 ulcerative colitis (UC) cases. No association was observed between total protein intake and IBD risk (adjusted HR for the fourth vs. the first quartile = 1.25; CI 95% = 0.89–1.77,
Conclusion
Animal protein intake is associated with IBD risk in the EPIC-IBD cohort. Observed associations between meat consumption and IBD or UC risk, and between red meat consumption and IBD or UC risk deserve further investigation.