Edouard Louis © ECCO

The BIOCYCLE project has now been ongoing for almost 2.5 years. This project, funded by the European Commission under the Horizon 2020 programme, aims at exploring different aspects of the question of treatment de-escalation in moderate-severe Crohn’s Disease, first requiring a combination therapy with anti-TNF and antimetabolites to control the disease. Once the disease has been stabilised, an unsolved question is to whether it is possible to de-escalate therapy. This question is important for several reasons including safety, tolerance, quality of life or costs to name the most prominent. 

Edouard Louis © ECCO

BIOCYCLE includes a randomised three-arm, controlled clinical trial on 300 patients in five European countries, several patient and health care provider surveys in Europe and the United States, a biomarker research programme and pharmaco-economic analysis. ECCO is mainly involved in the monitoring of the project (through SciCom and ClinCom) and is the work package leader for dissemination of the results. BIOCYCLE is a 6-year-long project and was launched in April 2015.  

Edouard Louis © ECCO

The BIOCYCLE project has now been ongoing for over 4 years. This project, funded by the European commission under the Horizon 2020 program, aims at exploring different aspects of the question of treatment de-escalation in moderate-severe Crohn’s disease, first requiring a combination therapy with anti-TNF and antimetabolites to control the disease. Once the disease has been stabilized, an unsolved question is to whether it is possible to de-escalate therapy. This question is important for several reasons including safety, tolerance, quality of life or costs to name the most prominent. Biocycle includes a randomized three arms, controlled clinical trial, called SPARE, on 200 patients in 6 European countries (France, United Kingdom, Belgium, Sweden, The Netherlands and Germany) and Australia, several patients and health care providers’ surveys in Europe and the USA, a biomarker research program and pharmaco-economic analysis. ECCO is mainly involved in the monitoring of the project (through the Sci Com and the Clin Com) and is the work package leader for dissemination of the results. Biocycle is a 7.5 years-long project and has been launched in April 2015.

Edouard Louis © ECCO

The BIOCYCLE project has now been ongoing for 5 years. This project, funded by the European Commission under the Horizon 2020 programme, aims to explore different aspects of the question of treatment de-escalation in moderate-severe Crohn’s Disease that first requires combination therapy with anti-TNF and antimetabolites to control the disease. Once the disease has been stabilised, an unsolved question is to whether it is possible to de-escalate therapy. This question is important for several reasons, including safety, tolerance, quality of life and costs, to name the most prominent. BIOCYCLE comprises nine work packages, including a randomised three-arm, controlled clinical trial on 210 patients in seven European countries, several patient and health care provider surveys in Europe and the United States, a biomarker research programme and pharmaco-economic analysis. ECCO is mainly involved in the monitoring of the project (through SciCom and ClinCom) and is the work package leader for dissemination of the results. BIOCYCLE is a 7.5-year project and was launched in April 2015.

Edouard Louis © ECCO

The BIOCYCLE project has now been ongoing for 7 years. This project, funded by the European Commission under the Horizon 2020 programme, aims to explore different aspects of the question of treatment de-escalation in moderate-severe Crohn’s Disease requiring a combination therapy with anti-TNF and antimetabolites to control the disease. An unsolved question is whether it is possible to de-escalate therapy once the disease has been stabilised. This question is important for several reasons, including safety, tolerance, quality of life and costs, to name the most prominent. BIOCYCLE includes a randomised, three-arm, controlled clinical trial on 210 patients in seven European countries, several patients’ and health care providers’ surveys in Europe and the United States, a biomarker research programme and pharmaco-economic analysis. ECCO is mainly involved in the monitoring of the project (through IBDIM) and is the work package leader for dissemination of the results. BIOCYCLE is a 7.5-year-long project and was launched in April 2015.

Edouard Louis © Edouard Louis

The BIOCYCLE project has now been ongoing for more than 7 years and is approaching its end. This project, funded by the European Commission under the Horizon 2020 programme, aims to explore different aspects of the difficult issue of treatment de-escalation in moderate to severe Crohn’s Disease first requiring a combination therapy with anti-TNF and antimetabolites to control the disease. Once the disease has been stabilised, an unsolved question is whether it is possible to de-escalate therapy. This question is important for several reasons, including safety, tolerance, quality of life and costs, to name the most prominent. BIOCYCLE includes a randomised three-arm, controlled clinical trial called SPARE, conducted on 200 patients in six European countries (France, United Kingdom, Belgium, Sweden, the Netherlands and Germany) and Australia, several patients’ and health care providers’ surveys in Europe and the United States, a biomarker research programme and pharmaco-economic analysis. ECCO is mainly involved in the monitoring of the project (through IBDIM) and is the work package leader for dissemination of the results. BIOCYCLE is a 7.5-year-long project and was launched in April 2015.