ECCO CONFER Cases

COllaborative Network For Exceptionally Rare case reports

CONFER Cases Round 12

Call for Proposals

ECCO CONFER is now opening the call for proposals for the 12^th round of ECCO CONFER Cases.

ECCO CONFER Call for proposals

Send your proposal to ecco@ecco-ibd.eu

Find out more

For more information on the format and content criteria, as well as the selection process, please find the full call.

Deadline to submit your proposal

October 27, 2025

Please find below further information on the cases.

Round 11 Cases

About

Unique and extraordinary clinical cases are generally reported in the form of a single case report or a small series, making it hard to derive clinical conclusions on modes of presentation, diagnosis, and treatment.

5 main themes of interest:

Unusual clinical situations facing diagnostic or therapeutic gaps of knowledge
Rare infections
Uncommon drug beneficial effects or side-effects
Rare IBD manifestations
Infrequent disease associations (neoplastic, infectious etc.)

What is ECCO CONFER Cases?

The ECCO CONFER Cases are based on an initiative introduced by the European Crohn’s and Colitis Organisation (ECCO) to support individual investigators in developing rare case series by collecting enough similar cases among the IBD Community. By joining forces of the many members and supporters of ECCO, a joint report of all similar such cases can result in a large case series that will advance knowledge on these uncommon patients.

How it operates

A call will be made once a year to all ECCO Members to propose CONFER case projects. Two to four cases will be selected by the CONFER Steering Committee.

The proposing investigator will act as PI and develop his/her case into a CONFER case project with the support of a member of the CONFER Steering Committee.

A call will then be made to all ECCO Members and affiliates who have encountered a similar case to contribute their case to the CONFER case series.

All received cases will be joined into a case series by a PI and prepared for publication.

ECCO’s support:

ECCO’s support includes dissemination of a call for similar cases, as well as assessment of the feasibility of the cases by the ECCO CONFER Steering Committee. It does not include any financial support nor any input in the collection of the data, the analysis or the publication of the data collected.

Members

Steering Committee

Mette Julsgaard

Denmark

Daniela Pugliese

Italy

Julien Kirchgesner

France

Marie Truyens

Belgium

Ongoing Cases:

CONFER Cases Round 11

Case 1

Effectiveness and Safety of Ozanimod and Natalizumab in Patients with Coexisting Inflammatory Bowel Disease and Multiple Sclerosis

More information about the Round 11 Case

Please contact ecco@ecco-ibd.eu if you want to receive more information on the cases and get in touch with the PIs.

CONFER Cases Round 10

Case 1

Perianal Crohn's fistula in the absence of luminal disease - natural history, time to progression to luminal disease and management in contemporary clinical practice

Case 2

Exposure to JAK-inhibitors during pregnancy and risk of adverse pregnancy outcome

Case 3

Safety and efficacy of JAK inhibitors in patients with primary sclerosing cholangitis associated with inflammatory bowel disease.

More information about Round 10 Cases

Please contact ecco@ecco-ibd.eu if you want to receive more information on the cases and get in touch with the PIs.

Previous Rounds of CONFER Cases:

CONFER Cases Round 9

Case 1

Treatment of chronic pouchitis with JAKs inhibitors and S1P receptor modulators

PI

Giulia Testa and Davide Ribaldone

Case Manager

Triana Lobaton

Manuscript published on JCC. DOI 1093/ecco-jcc/jjad194

Case 3

Biologicals and/or small molecules in patients with microscopic colitis

PI

Bram Verstockt

Case Manager

Mette Julsgaard

Submitted as an abstract to the ECCO Congress 2024 and published on JCC with the title “Promising efficacy of biologicals and small molecules for microscopic colitis: results from a large real-life multicenter cohort” (DOP79). DOI: 1093/ecco-jcc/jjad212.0119

CONFER Cases Round 8

Case 1

IBD and hidradenitis suppurativa

PI

Bram Verstockt

Case Manager

Idan Goren

Hard copy poster at ECCO’23 and published on JCC, with the title “P674 Ustekinumab is the preferred biological agent in IBD patients with hidradenitis suppurativa failing anti-TNF therapy: results from a real-life multicenter cohort”. DOI: https://doi.org/10.1093/ecco-jcc/jjac190.0804

Case 2

Safety and efficacy of ustekinumab and vedolizumab after liver transplant for PSC-IBD patients

PI

Triana Lobaton

Case Manager

David Drobne

Published on JCC with the title: "P621 Safety and effectiveness of vedolizumab and ustekinumab in inflammatory bowel disease patients after liver transplantation for primary sclerosing cholangitis: results from an ECCO-confer case series". DOI: https://doi.org/10.1093/ecco-jcc/jjad212.0751

Case 3

Solid organ transplant (but liver) in patients with inflammatory bowel disease

PI

Davide Ribaldone

Case Manager

Maria Chaparro

Hard copy poster at ECCO’23 and published on JCC with the title: “P252 Solid organ transplant (with the exception of liver) in patients with inflammatory bowel disease: An ECCO CONFER Multicentre Case Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjac190.0382

CONFER Cases Round 7

Case 1

Surgery due to inflammatory bowel disease during pregnancy: mothers and offspring outcomes

PI and Case Manager

Maria Chaparro

Hard copy poster at ECCO’22 and published on JCC with the title: "Surgery due to Inflammatory Bowel Disease During Pregnancy: Mothers and Offspring Outcomes From an ECCO Confer Multicentre Case Series [Scar Study]". DOI: https://doi.org/10.1093/ecco-jcc/jjac050

Case 2

A patient with ulcerative colitis and immune thrombocytopenic purpura

PI

Hussein Mahajna

Case Manager

Uri Kopylov

Hard copy poster at ECCO’22 and published on JCC with the title: "Hereditary Colorectal Cancer Syndromes and Inflammatory Bowel Diseases: an ECCO CONFER Multicentre Case Series". DOI: https://doi.org/10.1093/ecco-jcc/jjac094

Case 3

Hereditary Colorectal Cancer Syndromes and Inflammatory Bowel Diseases

PI

Brigida Barberio

Case Manager

Pierre Ellul

CONFER Cases Round 6

Case 1

New onset psoriasis following Vedolizumab treatment in IBD

PI

Josep Oriol Miquel Cusachs

Case Manager

Maria Chaparro

Case 2

Neuroendocrine neoplasms in patients with IBD

PI

Giulia Zerboni and Stefano Festa

Case Manager

Idan Goren

Published on JCC with the title: “Gastroenteropancreatic Neuroendocrine Neoplasms in Patients with Inflammatory Bowel Disease: An ECCO CONFER Multicentre Case Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjab217

Case 3

Primary Hypogammaglobulinaemia with IBD-like features

PI

Ahmad Albshesh

Case Manager

Uri Kopylov

Published on JCC with the title: “Primary Hypogammaglobulinaemia with Inflammatory Bowel Disease-Like Features”. DOI: https://doi.org/10.1093/ecco-jcc/jjab124

CONFER Cases Round 5

Case 1

Extranodal intestinal lymphoma in IBD (independent of treatment regimen)

PI

Frank Phillips

Case Manager

Konstantinos Karmiris

Published on JCC with the title: “Diagnosis and Outcome of Extranodal Primary Intestinal Lymphoma in Inflammatory Bowel Disease: An ECCO CONFER Case Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjab164;
“Corrigendum to: ECCO CONFER Investigators, Diagnosis and Outcome of Extranodal Primary Intestinal Lymphoma in Inflammatory Bowel Disease: An ECCO CONFER Case Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjac088

Case 2

Orofacial granulomatosis in Crohn’s Disease

PI

Frank Phillips

Case Manager

Pierre Ellul

Published on JCC with the title: “Orofacial Granulomatosis Associated with Crohn's Disease: a Multicentre Case Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjab158

Case 3

New onset spondyloarthropathy in IBD patients treated with VDZ

PI

Shaji Sebastian and Specialist Nurse Alison Tetley

Case Manager

Shaji Sebastian

Poster at ECCO’19 and published on JCC with the title: “P701 New onset spondyloarthropathy in vedolizumab treated IBD patients”. DOI: https://doi.org/10.1093/ecco-jcc/jjz203.829

CONFER Cases Round 4

Case 1

Drug Induced liver injury (DILI) with biologics

PI and Case Manager

Shaji Sebastian

Poster at ECCO’18 and published on JCC with the title: “P577 Drug Induced Liver Injury (DILI) secondary to biologic therapy in IBD: ECCO- CONFER Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjy222.701

Case 2

IBD and eosinophilic gastroenteritis (overlap cases)

PI

Kostantinos Katsanos

Case Manager

Uri Kopylov

Case 3

Esophageal Crohn's Disease

PI

Rita Rodrigues

Case Manager

Konstantinos Karmiris

Published on JCC with the title: “Diagnosis and Outcome of Oesophageal Crohn's Disease”. DOI: https://doi.org/10.1093/ecco-jcc/jjz201

Case 4

Upper and lower extremeties paresthesias under anti-TNFa therapy

PI

Konstantinos Katsanos

Case Manager

Gionata Fiorino

Published on JCC with the title: “Making a Case for Case Reports: The ECCO-CONFER Viewpoint on Investigating Rare Events in a Medical World Reigned by Group-comparative Statistics”. DOI: https://doi.org/10.1093/ecco-jcc/jjw131

CONFER Cases Round 3

Case 1

Pneumocystis jiroveci pneumonia in IBD patients treated with immunomodulator(s)

PI

Sophie Vieujean

Case Manager

Jean-François Rahier

Published on JCC, with the title “Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease–a Case Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjac153

Case 2

Granulomatous and interstitial lung disease in IBD

PI

Joana Moleiro and Elena Eliadou

Case Manager

Gionata Fiorino

Published on JCC with the title: "Inflammatory Cutaneous Lesions in Inflammatory Bowel Disease Treated With Vedolizumab or Ustekinumab: An ECCO CONFER Multicentre Case Series". DOI: https://doi.org/10.1093/ecco-jcc/jjz165

Case 3

Inflammatory cutaneous lesions in IBD treated with ustekinumab and vedolizumab

PI

Frank Phillips

Case Manager

Uri Kopylov

Published on JCC with the title: “Inflammatory Cutaneous Lesions in Inflammatory Bowel Disease Treated With Vedolizumab or Ustekinumab: An ECCO CONFER Multicentre Case Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjaa078

CONFER Cases Round 2

Case 1

Vulvitis granulomatosa or scrotal granulomatosa

PI

Frank Dederichs

Case Manager

Eugeni Domenech

Published on JCC, with the title “Genital Granulomatosis in Male and Female Patients With Crohn's Disease: Clinical Presentation and Treatment Outcomes”. DOI: https://doi.org/10.1093/ecco-jcc/jjx131

Case 2

PRES in anti-TNF treated patient

PI

John Puntis

Case Manager

Konstantinos Katsanos

Case 3

IBD patient undergoing thymectomy for myasthenia or for other indication

PI

Ren Mao

Case Manager

Shomron Ben-Horin

Case 4

Lymphangioma circumscriptum in an IBD patient

PI

Marc Ferrante

Case Manager

Jean-François Rahier

CONFER Cases Round 1

Case 1

Optic neuritis in patients treated or not with anti-TNF

PI

Benjamin Alexandre

Case Manager

Konstantinos Katsanos

Published on JCC, with the title “Optic Neuritis Associated or Not with TNF Antagonists in Patients with Inflammatory Bowel Disease”. DOI: https://doi.org/10.1093/ecco-jcc/jjw003

Case 2

Topical tacrolimus for the treatment of pouchitis

PI

Cyriel Ponsioen

Case Manager

Eugeni Domènech

Case 3

Cogan syndrome in patients with IBD

PI

Stephan Vavricka

Case Manager

Jean-François Rahier

Published on JCC, with the title “Cogan's Syndrome in Patients With Inflammatory Bowel Disease--A Case Series”. DOI: https://doi.org/10.1093/ecco-jcc/jjv128

Case 4

Cerebral vascular events (CVA/TIA) during anti-TNF treatment

PI

Konstantinos Karmiris

Case Manager

Shomron Ben-Horin

Published on JCC, with the title “Cerebrovascular events in inflammatory bowel disease patients treated with anti-tumour necrosis factor alpha agents”. DOI: https://doi.org/10.1093/ecco-jcc/jjv042