OP16 Influence of early life factors on the development of intestinal microbiota of infants born to mothers with and without IBD
J. Guedelha Sabino1,2,3, L. Tarassishin1, C. Eisele1, A. Barré1, M. Dubinsky4, J. Stone5, N. Nair1, A. Debebe1, K. Hawkins1, A. Rendon1, J. Hu1, J.F. Colombel3, P. Inga1, J. Torres3,6
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA, 2Division of Gastroenterology, University Hospital of Leuven, Leuven, Belgium, 3Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA, 4Division of Pediatric Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, USA, 5Department of Obstetrics, Gynecology and Reproductive Sciences, Icahn School of Medicine at Mount Sinai, New York, USA, 6Gastroenterology Division, Hospital Beatriz Ângelo, Loures, Portugal
Background
Inflammatory bowel diseases (IBD) are associated with a dysregulation of the intestinal microbiota and some of these dysbiotic taxa may be transmitted to the offspring of pregnant patients with IBD. We analysed the influence of early life events on the development of the intestinal microbiota of infants born to mothers with and without IBD.
Methods
The MECONIUM (Exploring MEChanisms Of disease traNsmission In Utero through the Microbiome) study is a prospective cohort study including pregnant women with or without IBD and their infants. Stool samples were collected during pregnancy and in babies throughout the first 2 years of life. Stool microbiota composition in the baby stool was assessed using 16S rRNA sequencing.
Results
We analysed 1037 faecal samples from 294 infants (born to 80 mothers with and 214 without IBD). The overall composition of the microbiota at 1 month was influenced by the mode of delivery (
Conclusion
Maternal IBD status is shaping early life microbiota in their offspring, likely due to altered microbiota in mothers with IBD. Additionally, the mode of delivery, feeding, and exposure to antibiotics are important determinants of the infant′s microbiota. These influences are lost with time, probably due to increasing exposure to several sources of microbiota and to confounding factors (e.g. diet).