ECCO CONFER Cases
COllaborative Network For Exceptionally
Rare case reports
COllaborative Network For Exceptionally
Rare case reports
CONFER CASES ROUND 11 – CALL FOR Similar Cases
ECCO CONFER is now opening the call for similar rare cases for the eleventh Round.
Case 1: Anti-TNF induced sarcoidosis in Inflammatory Bowel Diseases
Case 2: Effectiveness and Safety of Ozanimod and Natalizumab in Patients with Coexisting Inflammatory Bowel Disease and Multiple Sclerosis
For more information on the format and content criteria, as well as the selection, please find the full call below.
Updated deadline to submit your case proposal: (original deadline: March 15, 2025) April 15, 2025
Please respond to this call by sending your case to This email address is being protected from spambots. You need JavaScript enabled to view it..
Should you have any questions, do not hesitate to contact the ECCO Office.
Please find below further information on the cases.
About
Unique and extraordinary clinical cases are generally reported in the form of a single case report or a small series, making it hard to derive clinical conclusions on modes of presentation, diagnosis, and treatment.
5 main themes of interest:
- Unusual clinical situations facing diagnostic or therapeutic gaps of knowledge
- Rare infections
- Uncommon drug beneficial effects or side-effects
- Rare IBD manifestations
- Infrequent disease associations (neoplastic, infectious etc.)
What is ECCO CONFER Cases?
The ECCO CONFER Cases are based on an initiative introduced by the European Crohn’s and Colitis Organisation (ECCO) to support individual investigators in developing rare case series by collecting enough similar cases among the IBD Community. By joining forces of the many members and supporters of ECCO, a joint report of all similar such cases can result in a large case series that will advance knowledge on these uncommon patients.
How it operates
A call will be made once a year to all ECCO Members to propose CONFER case projects. Two to four cases will be selected by the CONFER Steering Committee.
The proposing investigator will act as PI and develop his/her case into a CONFER case project with the support of a member of the CONFER Steering Committee.
A call will then be made to all ECCO Members and affiliates who have encountered a similar case to contribute their case to the CONFER case series.
All received cases will be joined into a case series by a PI and prepared for publication.
ECCO’s support:
ECCO’s support includes dissemination of a call for similar cases, as well as assessment of the feasibility of the cases by the ECCO CONFER Steering Committee. It does not include any financial support nor any input in the collection of the data, the analysis or the publication of the data collected.
Steering committee
ECCO CONFER is managed by a five-member steering committee. The current steering committee is composed of:
Mette Julsgaard (Denmark)
Daniela Pugliese (Italy)
Julien Kirchgesner (France)
Marie Truyens (Belgium)
Ongoing cases
CONFER Cases Round 10
Case 1:
Perianal Crohn's fistula in the absence of luminal disease - natural history, time to progression to luminal disease and management in contemporary clinical practice
Case 2:
Exposure to JAK-inhibitors during pregnancy and risk of adverse pregnancy outcome
Case 3:
Safety and efficacy of JAK inhibitors in patients with primary sclerosing cholangitis associated with inflammatory bowel disease.
Please find below further information on the cases.
Please contact This email address is being protected from spambots. You need JavaScript enabled to view it. if you want to receive more information on the cases and get in touch with the PIs.
Previous CONFER Cases & Publications
Round 9
| Case 1 | Case Title: |
Treatment of chronic pouchitis with JAKs inhibitors and S1P receptor modulators |
| Principal Investigator: |
Giulia Testa and Davide Ribaldone | |
| Case Manager: | Triana Lobaton | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Treatment of Antibiotic Refractory Chronic Pouchitis With JAK Inhibitors and S1P Receptor Modulators: An ECCO CONFER Multicentre Case Series |
|
| DOI: |
| Case 2 | Case Title: |
Isolated Gastric Crohn's Disease achieving complete mucosal healing with biological therapies |
| Principal Investigator: |
Fadwa Adel Osama Ebada |
|
| Case Manager: | Daniela Pugliese |
| Case 3 | Case Title: |
Biologicals and/or small molecules in patients with microscopic colitis |
| Principal Investigator: |
Bram Verstockt | |
| Case Manager: | Mette Julsgaard | |
| Publication Type: |
DOP at ECCO´24 |
|
| Publication Title: |
DOP79 Promising efficacy of biologicals and small molecules for microscopic colitis: results from a large real-life multicenter cohort |
|
| DOI: |
| Case 4 | Case Title: |
Safety and efficacy of ustekinumab and vedolizumab after liver transplant for PSC-IBD patients |
| Principal Investigator: |
Tom Holvoet | |
| Case Manager: | Triana Lobaton | |
| Publication Type: |
Poster at ECCO´24 |
|
| Publication Title: |
P621 Safety and effectiveness of vedolizumab and ustekinumab in inflammatory bowel disease patients after liver transplantation for primary sclerosing cholangitis: results from an ECCO-confer case series |
|
| DOI: |
Round 8
| Case 1 | Case Title: |
Non anti-TNF therapy in patients with IBD and Hidradenitis Suppurativa |
| Principal Investigator: |
Bram Verstockt | |
| Case Manager: | Idan Goren | |
| Publication Type: |
Poster at ECCO’23 |
|
| Publication Title: |
P674 Ustekinumab is the preferred biological agent in IBD patients with hidradenitis suppurativa failing anti-TNF therapy: results from a real-life multicenter cohort |
|
| DOI: |
| Case 2 | Case Title: |
Solid organ transplant (but liver) in patients with inflammatory bowel disease |
| Principal Investigator: |
Davide Ribaldone | |
| Case Manager: | Maria Chaparro | |
| Publication Type: |
Poster at ECCO’23 Published on JCC |
|
| Publication Title: |
P252 Solid organ transplant (with the exception of liver) in patients with inflammatory bowel disease: An ECCO CONFER Multicentre Case Series Non-Hepatic Solid Organ Transplant in Patients with Inflammatory Bowel Disease: an ECCO CONFER Multicentre Case Series |
|
| DOI: |
Round 7
| Case 1 | Case Title: |
Surgery due to inflammatory bowel disease during pregnancy: mothers and offspring outcomes |
| Principal Investigator: |
Maria Chaparro | |
| Case Manager: | Maria Chaparro | |
| Publication Type: |
Poster at ECCO’22 Published on JCC |
|
| Publication Title: |
Surgery due to Inflammatory Bowel Disease During Pregnancy: Mothers and Offspring Outcomes From an ECCO Confer Multicentre Case Series [Scar Study] |
|
| DOI: |
| Case 2 | Case Title: |
A patient with ulcerative colitis and immune thrombocytopenic purpura |
| Principal Investigator: |
Hussein Mahajna | |
| Case Manager: | Uri Kopylov | |
| Publication Type: |
Poster at ECCO’22 Published on JCC |
|
| Publication Title: |
Hereditary Colorectal Cancer Syndromes and Inflammatory Bowel Diseases: an ECCO CONFER Multicentre Case Series |
|
| DOI: |
| Case 3 | Case Title: |
Hereditary Colorectal Cancer Syndromes and Inflammatory Bowel Diseases |
| Principal Investigator: |
Brigida Barberio | |
| Case Manager: | Pierre Ellul | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Hereditary Colorectal Cancer Syndromes and Inflammatory Bowel Diseases: an ECCO CONFER Multicentre Case Series |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjac094 |
| Case 4 | Case Title: |
IBD and type 2 autoimmune pancreatitis - the diagnostic dilemmas. How far is from theory to clinical practice? |
| Principal Investigator: |
Piotr Eder | |
| Case Manager: | Idan Goren | |
| Publication Type: |
Poster at ECCO’22 Published on JCC |
|
| Publication Title: |
Autoimmune pancreatitis in patients with inflammatory bowel disease - a real-world multicentre collaborative ECCO CONFER study |
|
| DOI: | 10.1093/ecco-jcc/jjad097. |
Round 6
| Case 1 | Case Title: |
New onset psoriasis following Vedolizumab treatment in IBD |
| Principal Investigator: |
Josep Oriol Miquel Cusachs | |
| Case Manager: | Maria Chaparro |
| Case 2 | Case Title: |
Neuroendocrine neoplasms in patients with IBD |
| Principal Investigator: |
Giulia Zerboni and Stefano Festa | |
| Case Manager: | Idan Goren | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Gastroenteropancreatic Neuroendocrine Neoplasms in Patients with Inflammatory Bowel Disease: An ECCO CONFER Multicentre Case Series |
|
| DOI: |
| Case 3 | Case Title: |
Primary Hypogammaglobulinaemia with IBD-like features |
| Principal Investigator: |
Ahmad Albshesh | |
| Case Manager: | Uri Kopylov | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Primary Hypogammaglobulinaemia with Inflammatory Bowel Disease-Like Features |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjab124 |
Round 5
| Case 1 | Case Title: |
Extranodal intestinal lymphoma in IBD (independent of treatment regimen) |
| Principal Investigator: |
Frank Phillips | |
| Case Manager: | Konstantinos Karmiris | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Diagnosis and Outcome of Extranodal Primary Intestinal Lymphoma in Inflammatory Bowel Disease: An ECCO CONFER Case Series Corrigendum to: ECCO CONFER Investigators, Diagnosis and Outcome of Extranodal Primary Intestinal Lymphoma in Inflammatory Bowel Disease: An ECCO CONFER Case Series |
|
| DOI: |
| Case 2 | Case Title: |
Orofacial granulomatosis in Crohn’s Disease |
| Principal Investigator: |
Frank Phillips | |
| Case Manager: | Pierre Ellul | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Orofacial Granulomatosis Associated with Crohn's Disease: a Multicentre Case Series. |
|
| DOI: |
| Case 3 | Case Title: |
New onset spondyloarthropathy in IBD patients treated with VDZ |
| Principal Investigator: |
Shaji Sebastian Specialist Nurse Alison Tetley |
|
| Case Manager: | Shaji Sebastian | |
| Publication Type: |
Poster at ECCO’19 |
|
| Publication Title: |
P701 New onset spondyloarthropathy in vedolizumab treated IBD patients |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjz203.829 |
Round 4
| Case 1 | Case Title: |
Drug Induced liver injury (DILI) with biologics |
| Principal Investigator: |
Shaji Sebastian | |
| Case Manager: | Shaji Sebastian | |
| Publication Type: |
Poster at ECCO´18 |
|
| Publication Title: | P577 Drug Induced Liver Injury (DILI) secondary to biologic therapy in IBD: ECCO- CONFER Series | |
| DOI: |
| Case 2 | Case Title: |
IBD and eosinophilic gastroenteritis (overlap cases) |
| Principal Investigator: |
Kostantinos Katsanos | |
| Case Manager: | Uri Kopylov |
| Case 3 | Case Title: |
Esophageal Crohn's Disease |
| Principal Investigator: |
Rita Rodrigues | |
| Case Manager: | Konstantinos Karmiris | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Diagnosis and Outcome of Oesophageal Crohn's Disease |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjz201 |
| Case 4 | Case Title: |
Upper and lower extremeties paresthesias under anti-TNFa therapy |
| Principal Investigator: |
Konstantinos Katsanos | |
| Case Manager: | Gionata Fiorino | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Making a Case for Case Reports: The ECCO-CONFER Viewpoint on Investigating Rare Events in a Medical World Reigned by Group-comparative Statistics. |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjw131 |
Round 3
| Case 1 | Case Title: |
Pneumocystis jiroveci pneumonia in IBD patients treated with immunomodulator(s) |
| Principal Investigator: |
Sophie Vieujean | |
| Case Manager: | Jean-François Rahier | |
| Publication Type: |
Published on JCC |
|
| Publication Title: | Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease–a Case Series | |
| DOI: | https://doi.org/10.1093/ecco-jcc/jjac153 |
| Case 2 | Case Title: |
Granulomatous and interstitial lung disease in IBD |
| Principal Investigator: |
Joana Moleiro Elena Eliadou |
|
| Case Manager: | Gionata Fiorino | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Inflammatory Cutaneous Lesions in Inflammatory Bowel Disease Treated With Vedolizumab or Ustekinumab: An ECCO CONFER Multicentre Case Series. |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjz165 |
| Case 3 | Case Title: |
Inflammatory cutaneous lesions in IBD treated with ustekinumab and vedolizumab |
| Principal Investigator: |
Frank Phillips | |
| Case Manager: | Uri Kopylov | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Inflammatory Cutaneous Lesions in Inflammatory Bowel Disease Treated With Vedolizumab or Ustekinumab: An ECCO CONFER Multicentre Case Series. |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjaa078 |
Round 2
| Case 1 | Case Title: |
Vulvitis granulomatosa or scrotal granulomatosa |
| Principal Investigator: |
Frank Dederichs | |
| Case Manager: | Eugeni Domenech | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Genital Granulomatosis in Male and Female Patients With Crohn's Disease: Clinical Presentation and Treatment Outcomes. |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjx131 |
| Case 2 | Case Title: |
PRES in anti-TNF treated patient |
| Principal Investigator: |
John Puntis | |
| Case Manager: | Konstantinos Katsanos |
| Case 3 | Case Title: |
IBD patient undergoing thymectomy for myasthenia or for other indication |
| Principal Investigator: |
Ren Mao | |
| Case Manager: | Shomron Ben-Horin |
| Case 4 | Case Title: |
Lymphangioma circumscriptum in an IBD patient |
| Principal Investigator: |
Marc Ferrante | |
| Case Manager: | Jean-François Rahier |
Round 1
| Case 1 | Case Title: |
Optic neuritis in patients treated or not with anti-TNF |
| Principal Investigator: |
Benjamin Alexandre | |
| Case Manager: | Konstantinos Katsanos | |
| Publication Type: |
Published on JCC |
|
| Publication Title: | Optic Neuritis Associated or Not with TNF Antagonists in Patients with Inflammatory Bowel Disease. |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjw003 |
| Case 2 | Case Title: |
Topical tacrolimus for the treatment of pouchitis |
| Principal Investigator: |
Cyriel Ponsioen | |
| Case Manager: | Eugeni Domènech |
| Case 3 | Case Title: |
Cogan syndrome in patients with IBD |
| Principal Investigator: |
Stephan Vavricka | |
| Case Manager: | Jean-François Rahier | |
| Publication Type: |
Published on JCC |
|
| Publication Title: |
Cogan's Syndrome in Patients With Inflammatory Bowel Disease--A Case Series. |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjv128 |
| Case 4 | Case Title: |
Cerebral vascular events (CVA/TIA) during anti-TNF treatment |
| Principal Investigator: |
Konstantinos Karmiris | |
| Case Manager: | Shomron Ben-Horin | |
| Publication Type: |
Published on JCC |
|
| Publication Title: | Cerebrovascular events in inflammatory bowel disease patients treated with anti-tumour necrosis factor alpha agents. |
|
| DOI: | https://doi.org/10.1093/ecco-jcc/jjv042 |