P051 Quantifying inflammation and fibrosis through a surgical histopathological score can differentiate ileal Crohn’s disease phenotypes and predict postoperative progressive disease
H. Tavares de Sousa1,2, I. Gullo3,4,5, C. Castelli6, C.C. Dias7,8, F. Magro9,10,11
1Algarve University Hospital Centre, Gastroenterology Department – Portimão Unit, Portimão, Portugal, 2ABC – Algarve Biomedical Centre, University of Algarve, Faro, Portugal, 3São João University Hospital and Faculty of Medicine, Department of Pathology, Porto, Portugal, 4University of Porto, Institute of Investigation and Inovation in Health i3S, Porto, Portugal, 5Institute of Molecular Pathology and Immunology of the University of Porto Ipatimup, Institute of Molecular Pathology and Immunology of the University of Porto Ipatimup, Porto, Portugal, 6University and Hospital Trust of Verona, Department of Diagnostics and Public Health- section of Pathology, Verona, Italy, 7Faculty of Medicine, University of Porto, Portugal, Department of Community Medicine, Information and Decision in Health, Porto, Portugal, 8University of Porto, Centre for Health Technology and Services Research, Porto, Portugal, 9Faculty of Medicine, University of Porto, Department of Biomedicine, Unit of Pharmacology and Therapeutics, Porto, Portugal, 10MedInUP, Centre for Drug Discovery and Innovative Medicines, MedInUP, Centre for Drug Discovery and Innovative Medicines, Porto, Portugal, 11São João University Hospital, Department of Gastroenterology, Porto, Portugal
Background
The quantification of fibrosis in Crohn’s disease (CD) still relies on surgical specimens’ pathology. We aimed to correlate quantification of inflammation and fibrosis of CD ileal resection specimens with postoperative progressive disease.
Methods
All patients (patients) having primary ileal resection for CD complications with a follow-up >3 years (
Results
We assessed 103 patients (B2–29; B3o–20; B3s–54), 55% males, mean age at diagnosis 30(12) years, followed for a mean time of 10(4) years. Median time from surgery to reoperation was 8.0 (7.0, 12.0) years. B3 patients have significantly more inflammation than B2 patients [score 3: 78%vs.55% and 96%vs.76% in most affected (
Conclusion
B3s stood out as a distinctive phenotype, with significantly more fibrosis than B3o but significantly more inflammation than B2. It displayed the highest total score and was associated to progressive disease.
- Posted in: Poster presentations: Basic Science 2020