P082 Spicy food is a vital trigger for relapse in patient with inflammatory bowel disease
Y. Chen, C. Ma, Y. Dang, K. Chen, S. Shen, M. Jiang, Z. Zeng, H. Zhang
West China Hospital, Gastroenterology, Chengdu, China
Background
The dietary is one of the environmental triggers for inflammatory bowel disease (IBD). We investigated which types of food can induce the relapse and worsen the symptoms in IBD patients through the epidemiologic study, and then explored the underlying mechanisms in an animal study.
Methods
A questionnaire assessing demographics, dietary habits and relapse-associated risk factors in patients has been administered to consecutive IBD patients who suffered one or more relapses at West China Hospital from September 2016 to November 2018. The mice with dextran sulphate sodium (DSS)-induced chronic colitis were orally administrated with top one type of risk food. The severity of mice colitis after administration was evaluated by disease activity index (DAI), histology, activity of myeloperoxidase (MPO) and the level of inflammatory cytokines. The infiltration of immune cells in lamia propria (LP) of mice was analysed by flow cytometry (FCM).
Results
A total of 306 patients participated in the survey, including 188 ulcerative colitis (UC) patients and 118 Crohn’s disease (CD) patients. Spicy food ranked first for the relapse in patients with IBD. In particular, 54.3% (
Conclusion
The intake of spicy food can contribute to the relapse and deterioration of symptoms in IBD patients with UC and CD. In mice, the oral administration of capsaicin exacerbated DSS-induced colitis which was characterised by the recruitment of neutrophils, indicating the association between neutrophils and the relapse-triggering effect of capsaicin in colitis.