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Poster presentations: Clinical: Diagnosis and Outcome 2020

P253 The prevalence of type 6 herpes with polyps in patients with inflammatory bowel disease

G. Babayeva-Sadigova1, Z. Babayev2, U. Mahmudov3, G. Asadova4, F. Quliyev5, O. Mirzazade6

1IBD group, 1A.Aliyev’s State Advanced Training Institute for Doctors, Department of Therapy- IBD group, Baku, Azerbaijan, 2Memorial klinika, IBD therapy department, Baku, Azerbaijan, 3Modern Hospital, gastroenterology and endoscopy department, Baku, Azerbaijan, 4National Center of Oncology, Department of Invasive diagnosis and therapy, Baku, Azerbaijan, 5Oksigen Klinika, gastroenterology and endoscopy department, Baku, Azerbaijan, 6A.Aliyev’s State Advanced Training Institute for Doctors, Department of Therapy- IBD group, Baku, Azerbaijan

Background

The prevalence of opportunistic infections in individuals with inflammatory bowel disease (IBD) remains relevant. Viral infections are a common cause of systemic inflammation of the digestive tract. Clinically expressed herpes infections are a serious problem, especially for individuals with prolonged immunosuppression. The aim of this study was

Methods

t:

o assess the frequency of detection of herpes-6 type with polyps in patients with IBD.

Results

189 patients with IBD, 102 with ulcerative colitis and 87 with Crohn’s disease were examined. Of the number of patients: 98women, 91man. The age of the patients is from 16 to 63 years (mean age 41.4 ± 4.8), out of 189 patients intestinal polyps were identified in 61 patients with a colonoscopy. In addition to standard clinical and endoscopic examinations, disease activity was assessed by indicators of highly sensitive C-reactive protein, homocysteine, vitamin D in blood serum, albumin in urine, calprotectin, lactoferrin and pyruvate kinase in faeces. All patients underwent a serological blood test by ELISA for specific antibodies to herpesvirus type 1–6 IgG/IgM antibodies, as well as avidity, determination of DNA to herpes viruses of types 1–6 species by PCR in blood and mucosal biopsy.

Conclusion

Among patients with IBD (n = 189), active herpes viruses in the blood were found in 65 patients (34.4%); of them, 39 patients (20.6% (n = 189) and 60%(n = 65),respectively) were diagnosed with monoherpesvirus infections, and 26 (13.7%(n = 189) and 40%(n = 65), respectively) of myxedvirus infections. PCR of the biopsy material was positive in isolation for type 6 herpes virus in 22 cases (11.6% (n = 189) and 33.8% (n = 65)) and in 34 cases (17.9% (n = 189) and 52.3% (n = 65)) a myxedvirus lesion was detected in the tissue (HV6 + EPB, HV6 + CMV), these indicators were detected in patients with intestinal polyps. Although clinical and endoscopic and laboratory indicators of disease activity were significantly higher in patients with mixed tissue lesions (p˂0.05), the level of faecal pyruvate kinase was higher in patients with polyps, indicating a negative effect of herpes type 6 on the course of inflammatory bowel diseases. At the same time, no significant differences were found between patients with ulcerative colitis and Crohn’s disease.

The frequency of occurrence of herpes type 6 on PCR biopsy in patients with polyps with IBD is more than 91.8% (36.5% in isolation and 55.7% of mixed lesions) and is accompanied by higher rates of faecal pyruvate kinase, which is already an indicator of emerging malignancy. The authors propose the determination of polyps in patients with IBD HV6 by PCR biopsy of intestinal tissue.