P310 Atopic dermatitis is associated with the clinical course of Inflammatory Bowel Disease
Kim, K.W.(1);Ha, H.(2);Jun, Y.(1);Lee, H.J.(1);Yoon, H.(3);Kang, H.W.(4);Im, J.P.(1);Kim, J.S.(1);Koh, S.J.(1);
(1)Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea- Republic Of;(2)Seoul National University College of Medicine, Medical school, Seoul, Korea- Republic Of;(3)Seoul National University Bundang Hospital, Department of Internal Medicine, Seongnam-si, Korea- Republic Of;(4)Seoul National University Boramae Medical Center, Department of Internal Medicine, Seoul, Korea- Republic Of;
Background
There are a few studies about the relationship between inflammatory bowel disease (IBD) and atopic dermatitis (AD). It implicates that both diseases have common pathophysiologic mechanism and are able to affect each other. However, little information is available for the effect of AD on the clinical course of patients with IBD.
Methods
This is a retrospective, observational case-control study. Patients with concurrent IBD and AD were defined as case group and those with IBD only as control group. Diagnosis of AD was defined as chronic eczematoid dermatosis diagnosed by dermatologists. Age-, gender-, and IBD subtype-matched patients with a confirmed diagnosis of IBD were included as control group. The ratio of the case and control group was set as 1:2. Trend in the duration from diagnosis of IBD to first use of biologics, first IBD-related operation and first IBD-related bowel resection were estimated with Cox regression analysis.
Results
The numbers of patients in the case and control group were 31 and 62, respectively. Compared with the control group, the case group showed an earlier disease onset (unit: years, 22.13 ± 10.66 vs. 17.68 ± 8.07, p = 0.043) and longer disease duration of IBD (unit: months, 98.37 ± 69.24 vs. 150.77 ± 83.45, p = 0.002). In addition, the proportion of biologics use (35% vs. 61%, p = 0.018) and the total numbers of biologics usages (0.48 ± 0.76 vs. 1.06 ± 1.12, p = 0.013) were higher in patients in the case group than those in the control group. In the Cox-regression analysis, there was a significant decrease of the duration for the biologics free survival in the case group compared with the control one after the adjustment with age, IBD subtype, onset age and disease duration (p < 0.001).
Conclusion
Patients having concurrent IBD and AD exhibited different characteristics compared with those having IBD only, particularly in terms of disease onset and severity. Furthermore, AD showed an significant effect on the time for the initiation of biologics. Further research is required to elucidate the common pathogenesis and the role of AD on the clinical course of IBD.