P349 Safety of Inflammatory Bowel Disease treatments in patients with Solid Organ Transplantation (EITOS study of GETECCU).
Bastón Rey, I.(1);Calvino Suárez, C.(1);Luque, A.M.(2);Caballol, B.(3);Soutullo, C.(4);Bravo, A.(5);Castaño, A.(6);Gros, B.(7);Hurtado, A.(8);Vázquez Rey, T.(9);Alonso Galán, H.(10);Cañete, F.(11);Castro, B.(12);Pérez Galindo, P.(13);González Muñoza, C.(14);El Hajra, I.(15);Martínez Montiel, P.(16);Alonso Abreu, I.(17);Mesonero, F.(18);González Vivo, M.(19);Peries, L.(20);Martín Arranz, E.(21);Abril, C.(22);Marín Jiménez, I.(23);Baltar, R.(24);Vicuña, M.(25);Moreno, N.(26);Brunet, E.(27);Rodríguez Lago, I.(28);Rubín de Célix, C.(29);Fajardo, I.(30);Cruz, N.(31);Rojas Feria, M.(2);Fernández Clotet, A.(3);Gimeno, M.(4);Zabana, Y.(32);Suárez Ferrer, C.(21);Barreiro de Acosta, M.(1);
(1)Hospital Clínico Universitario de Santiago, Department of Gastroenterology, Santiago De Compostela, Spain;(2)Hospital Universitario Virgen del Rocío, Gastroenterology Department, Sevilla, Spain;(3)Hospital Clinic de Barcelona, Gastroenterology Department, Barcelona, Spain;(4)Hospital Universitario y Politécnico La Fe, Gastroenterology Department, Valencia, Spain;(5)Hospital Regional Universitario de Málaga, Gastroenterology Department, Málaga, Spain;(6)Hospital Universitario Central de Asturias, Gastroenterology Department, Oviedo, Spain;(7)Hospital Universitario Reina Sofía, Gastroenterology Department, Córdoba, Spain;(8)Hospital General de Alicante. Instituto de Investigación Sanitaria y Biomédica de Alicante ISABIAL, Gastroenterology Department, Alicante, Spain;(9)Complexo Hospitalario Universitario A Coruña, Gastroenterology Department, A Coruña, Spain;(10)Hospital Universitario Donostia and Biodonostia Health Research Institute, Gastroenterology Department, San Sebastián-Gipuzkoa, Spain;(11)Hospital Universitari Germans Trias i Pujol. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Department, Barcelona, Spain;(12)Hospital Universitario Marqués de Valdecilla, Gastroenterology Department, Santander, Spain;(13)Complexo Hospitalario Universitario de Pontevedra, Gastroenterology Department, Pontevedra, Spain;(14)Hospital Santa Creu i Sant Pau, Gastroenterology Department, Barcelona, Spain;(15)Hospital Universitario Puerta de Hierro, Gastroenterology Department, Madrid, Spain;(16)Hospital Universitario 12 de Octubre, Gastroenterology Department, Madrid, Spain;(17)Hospital Universitario de Canarias, Gastroenterology Department, Tenerife, Spain;(18)Hospital Universitario Ramón y Cajal, Gastroenterology Department, Madrid, Spain;(19)Hospital del Mar, Gastroenterology Department, Barcelona, Spain;(20)Hospital Josep Trueta, Gastroenterology Department, Girona, Spain;(21)Hospital Universitario La Paz, Gastroenterology Department, Madrid, Spain;(22)Hospital Clínico Universitario de Valencia, Gastroenterology Department, Valencia, Spain;(23)Hospital General Universitario Gregorio Marañón, Gastroenterology Department, Madrid, Spain;(24)Hospital Universitario de Álava, Gastroenterology Department, Vitoria, Spain;(25)Complejo Hospitalario Universitario de Navarra, Gastroenterology Department, Navarra, Spain;(26)Hospital Doctor Peset, Gastroenterology Department, Valencia, Spain;(27)Hospital Universitari Parc Taulí, Gastroenterology Department, Sabadell, Spain;(28)Hospital Universitario de Galdakao and Biocruces Bizkaia Health Research Institute, Gastroenterology Department, Galdakao, Spain;(29)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-IP, Gastroenterology Department, Madrid, Spain;(30)Hospital Universitari Mútua Terrasa, Gastroenterology Department, Barcelona, Spain;(31)Hospital Doctor José Molina Orosa, Gastroenterology Department, Lanzarote, Spain;(32)Hospital Universitari Mútua Terrasa. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology Department, Barcelona, Spain; young GETECCU
Background
Inflammatory bowel disease (IBD) in patients with solid organ transplantation (SOT) is associated with a greater complexity in their medical management. The aim of this study was to evaluate the safety profile of different IBD treatments in patients with IBD and SOT.
Methods
A retrospective, observational multi-center study was designed. IBD patients with SOT were included in two separate cohorts: (1) patients with pre-existing IBD and (2) patients without IBD at the time of SOT (de novo IBD). The primary outcome was to evaluate the presence of severe infections (opportunistic infections or infection that required hospitalization) and malignancies. Predictive factors for infections were identified by logistic regression.
Results
A total of 177 patients (106 pre-existing IBD and 71 de novo IBD) from 31 centers were included. Baseline characteristics are shown in Table 1. Tacrolimus was the most commonly used antirejection treatment (153 patients, 88.7%).
In the pre-existing IBD cohort, after SOT, 61 patients (59.8%) were not under treatment or were treated with 5-aminosalicylates, 10 patients (9.8%) were on azathioprine and 31 (30.4%) were on biologics, of which 8 were on combo therapy. In the pre-existing IBD cohort, 47.1% patients had severe infections being cytomegalovirus (CMV) infection, acute cholangitis and Clostridioides difficile (C.Diff) colitis the most common (Fig. 1).
In de novo IBD cohort, 13 patients (18.3%) were on azathioprine and 28 (39.4%) were on biologics, of which 4 were on combo therapy. Half of patients in de novo IBD cohort (54.9%) had severe infections, being CMV infection and pneumonia the most frequently observed. C.Diff colitis was less frequent in this group (Fig 2).
Asystole donor (OR 3.7, 95%CI 1.1-12.6), primary sclerosing cholangitis (PSC) (OR 3.3, 95%CI 1.3-8.6) and retransplantation (OR 10.8, 95%CI 1.2-98.8) were identified as risk factors for severe infection after SOT in patients with pre-existing IBD. No treatment was significantly associated with increased risk of infections.
In the pre-existing IBD cohort, 14 (13.5%) developed at least one malignancy after SOT over a median of 5 years (range 1.2-10.1). In patients with de novo IBD, 13 (18.3%) developed cancer after the diagnosis of IBD over a median of 6.6 years (range 2.9-8.0). Non-melanoma skin cancer was the most frequent malignancy in both groups. Two colorectal cancers were detected in each cohort.
Conclusion
About half of patients with IBD and SOT develop severe infections, being CMV the most frequent involved. Asystole donor, PSC and retransplantation are associated with increased risk of infection after SOT in pre-existing IBD cohort. Both groups show an elevated incidence of malignancies, being non-melanoma skin cancer the most common.