P392 Initial experience with fibrin glue combined with infliximab treatment of postoperative anastomotic fistula in patients with Crohn’s disease
D. YAO
Department of General Surgery Shanghai Ninth People’s Hospital Shanghai Jiaotong University School of Medicine, No. 639 of Zhizaoju Road, General Surgery, Shanghai, China
Background
Postoperative anastomotic fistula is one of the most frequent and potentially life-threatening complications following gastrointestinal resections in patients with Crohn’s disease. The purpose of this study was to report the results of using infliximab to treat postoperative anastomotic fistula in patients with Crohn’s disease.
Methods
A prospective parallel study of fibrin glue combined with infliximab vs. fibrin glue treatment was conducted. Demographic and clinical characteristics and outcomes were compared between the groups.
Results
Thirty-five patients with postoperative anastomotic fistula were evaluated; 14 received fibrin glue combined with infliximab treatment and 21 received fibrin glue treatment. No significant differences in demographic or clinical characteristics were found between the two groups (all
Conclusion
Infliximab strategy with combining fibrin glue is a simple and effective treatment alternative in the management of postoperative anastomotic fistula in Crohn’s disease.