P436 Evaluation of targeted vitamin D supplementation regimen in postoperative patients with Crohn’s disease
Y. LI, L. Zheng, D. Yao, Z. Zhou, B. Liu, Y. Huang, Y. Duan
Department of Surgery, Shanghai Ninth People’s Hospital -Shanghai Jiaotong University School, Shanghai, China
Background
Vitamin D with a serum 25(OH)D concentration above 100 nmol/l was associated with disease remission in patients with IBD and suggested that targeted administration may be an anti-inflammatory drug. This study was designed to assess the effectiveness, safety, and predictive measures of a vitamin D regimen in postoperative patients with Crohn’s disease to achieve the above goals.
Methods
In a prospective study, patients with Crohn’s disease and serum 25(OH)D concentrations <75 nmol / L were prescribed an oral vitamin D supplement at a dose of one year, and adjusted 4-weekly to aim for a serum 25(OH)D level of 100–125 nmol/l.
Results
Thirty-two postoperative patients with Crohn’s colitis had an average 25(OH)D concentration of 51.5 (range 25–74 nmol / L). 25 patients reached the target level and six patients reached 90–94 nmol / L. Because of the reoperation, one patient withdrew in 6 months. Patients with BMI <30 kg / m2 could reach the target dose (
Conclusion
Specific oral vitamin D regimens can successfully and safely reach or approach target levels, improve symptom-based activity scores, but do not alter objective indicators of intestinal or systemic inflammation. A modified version of this dose-escalation protocol is suitable for randomised placebo-controlled trials, and the further randomised controlled trial was needed.