P688 Sex difference in inflammatory bowel disease patients regarding depression: a nationwide population based study in Korea

Moon, J.M.(1);Han, K.(2);Shin, S.Y.(1);Choi, C.H.(1);Kim, J.S.(3);

(1)Chung-Ang University College of Medicine, Department of Internal Medicine, Seoul, Korea- Republic Of;(2)Soongsil University, Department of Statistics and Actuarial Science, Seoul, Korea- Republic Of;(3)Seoul National University College of Medicine, Department of Internal Medicine- Liver Research Institute, Seoul, Korea- Republic Of;


Inflammatory bowel disease (IBD) patients are often exposed to the risks of developing psychological symptoms such as anxiety or depression. We aimed to investigate sex difference regarding incidence of depression among Korean IBD patients.


A cohort involving a total of 133,216 subjects were established using Korean HIRA (health insurance review & assessment service) database from January 2009 to December 2017. Newly diagnosed IBD patients were 47,416, according to the International Classification of Diseases, 10th revision (ICD-10). From the newly diagnosed IBD population, we defined incidence of depression using the ICD-10 code.


Among the IBD population, 27,172 (57.3%) were male and they were slightly younger than female (39.09 and 39.81, p<001). During the follow-up period, a total of 5,355 were newly diagnosed as depression. The incidence of depression were more evident in the female both in ulcerative colitis (incidence ratio, IR, per 1000 of 23.55 and 32.81, to male and female, respectively) and crohn’s disease (IR per 1000 of 16.24 and 30.76, respectively) This trend was consistent even with variables adjusted to age, diabetes, hypertension and medication use (biologics, steroids, 5-ASA, immunomodulators and antibiotics) Female IBD patients were at an increased risk of developing depression compared to male with a hazard ratio of 1.40 (1.33-1.48, p<0.001). Further subgroup analyses were performed according to age, co-morbidities and biologics use, revealing similar results.


Risk of depression was elevated in Korean female IBD patients compared to males. Gastroenterologists managing IBD patients on clinics should be well aware of gender-specific issues regarding depression.