P865 Anxiety and Depression is Associated with Poor Sleep Quality in patients with Inflammatory Bowel Disease (IBD)

Connaughton, R.(1)*;Kafienah, Y.(2);Ramkalawan, K.(2);Stacey, W.(2);Walker, C.(1);O'Donnell, S.(1);Ryan, B.(1);O'Connor, A.(1);

(1)Tallaght University Hospital, Gastroenterology, Dublin, Ireland;(2)Trinity College Dublin, School of Medicine, Dublin, Ireland; Tallaght University Hospital Dublin Ireland


Sleep disturbances affect 40-50% of patients with IBD and are associated with disease flares. Symptoms, treatment side effects and pro-inflammatory status have been shown to have an effect on sleep quality and duration. Anxiety and Depression disorders are also common with both conditions affecting approximately 20% of IBD patients. These disorders may also be associated with sleep disturbance


Our primary aim was to assess for a correlation between sleep quality and mood disorders in people with IBD. Our secondary aim was to assess the impact of these factors on quality of life.


87 patients with IBD were invited to complete an online survey. This survey included general demographic information, inflammatory bowel disease information, Pittsburgh Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), disease activity scores (Harvey Bradshaw Index and partial MAYO score), and the Short Inflammatory Bowel Disease Questionnaire (SIBDQ). One-way ANOVA tests, Fisher’s test and unpaired t-tests were used to calculate the statistical significance.


  • Mean age 43years. 46% male (n=40) and 54% female (n=47). Ulcerative Colitis 35.6% (n=31), Crohn’s Disease 62.1% (n=54), and indeterminate 2.3% (n=2).

    The mean global PSQI score was 7.66, with 62% (n=54) of participants having a global PSQI score >5, indicating poor sleep quality.

    Poor sleep quality was not associated with age or disease duration. However unsurprisingly, it was associated with increased disease activity; Remission 5.89, mild activity 7.53, and moderate activity 10.61 (p<0.001). See FIGURE 1
  • Participants with poor quality of sleep had significantly higher rates of anxiety (HADSA >8) with a mean HADS anxiety score of 10.78  with 79% (n=39/49) reporting anxiety, compared to those with good reported sleep with mean scores of 4.97 and 21% (n=7/33).reporting anxiety p<0.001. They also had higher rates of depression, 42%(n=21/49) versus 6%(n=2/33), p<0.001.


Poor sleep quality increases levels of anxiety and depression, which in turn impacts quality of life in patients with IBD. Physicians should enquire about sleep & mood when treating patients with IBD to improve sleep quality.