P890 Prevalence and Characteristics of Extra-intestinal Manifestations in a single cohort of Italian Patients with Inflammatory Bowel Disease

Marino, M.(1)*;Sigura, E.(2);Castagnaviz, E.(3);Dottor, F.(2);Colombo, A.(1);Solito, S.(1);Terrosu, G.(4);Buda, A.(5);Berretti, D.(1);

(1)Azienda Sanitaria Universitaria Friuli Centrale, Department of Gastroenterology, Udine, Italy;(2)Azienda sanitaria universitaria Giuliano Isontina, Clinica Patologie del Fegato, Trieste, Italy;(3)Azienda Sanitaria Universitaria Friuli Centrale, Rheumatology, Udine, Italy;(4)Azienda Sanitaria Universitaria Friuli Centrale, Surgery, Udine, Italy;(5)Gastroenterology, Gastrointestinal Oncological Surgery Department, Feltre, Italy;


Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder comprised of Crohn disease (CD) and ulcerative colitis (UC). Patients with IBD may present extraintestinal manifestations (EIMs) that may affect different district such as joints, skin, eyes, and hepatobiliary area. Our objective is to characterize and determine the prevalence of EIMs in our cohort of patients affected with IBD


The study population consisted of IBD patients who were followed in one single tertiary Centre in North East Italy. Retrospectively demographic and clinical characteristics of patients were analysed. The diagnosis of EIMs was based on standard criteria and on specialist consultation.


Our registry has 904 patients with IBD (M/F 484/420), 536 have UC (59,29%), 355 CD (39,26%) and 13 unclassified IBD (1.43%). Among them 170 patients (18,80%) presented at least one EIMs, 82 of 536 (15,29%) with UC and 81 of 335 (24,17%) with CD. The median age of these patients was 48 years old (36-57) and EIMs were more prevalent in females (55.6%) and in patients with younger age (57.7% with age range between 17-40 y.o.). In most of the patients (67.64%) were present more than one EIMs. Regarding the type of EIMs, the articular ones were by far the most frequent (67.7%) than followed by other manifestations: mucocutaneous (32.4%), hepatobiliary (11.2%), ocular (10.0%), pancreatic (5.9%), coagulation (3.5%), pulmonary (2.4%), muscular (1.2%), hearing loss (1.2%) and cardiac (1.2%). Furthermore EIMs were also more prevalent in smokers [p <0.001], patients with extensive UC [p = 0.008] and patients with major IBD-related surgery [p = 0.015]


Our study confirm that about one-fifth of patients with IBD may have associated EIMs with rheumatic manifestations, by far, the most frequent symptom. CD and female patients with severe Crohn's disease represent the group with the highest risk of developing EIMs followed by smokers, extensive UC and with previous major IBD surgery. These patients should therefore be specially monitored and referred to the corresponding specialist when suggestive symptoms appear.