P892 Characteristics and trend of Inflammatory Bowel Disease epidemiology for 30 years from 1991 to 2020: A single-center experience analysis in Incheon, Korea
Na, S.Y.(1)*;Choi, H.(1);Ji, J.S.(1);Kim, S.Y.(2);
(1)Incheon St. Mary’s Hospital- College of Medicine- The Catholic University of Korea, Internal Medicine, Incheon, Korea- Republic Of;(2)Incheon St. Mary’s Hospital- College of Medicine- The Catholic University of Korea, Pediatrics, Incheon, Korea- Republic Of;
Background
Inflammatory bowel disease (IBD) in Asia is different from that of the West in incidence, prevalence, clinical features, and genetic mutations. The purpose of this study was to investigate changes in the characteristics and trends in patients with IBD over 30 years in a single center in Incheon, Korea.
Methods
Among 1,070 IBD patients (Crohn’s disease [CD] 286; ulcerative colitis [UC] 784) who visited from Jan 1991 to Dec 2020, 773 patients (CD 204; UC 569) who were first diagnosed and followed for more than 1 year were enrolled. The demographic characteristics and trends of IBD patients for 30 years of IBD were analyzed retrospectively by dividing them into three periods.
Results
In CD, the age at diagnosis gradually decreased from 24.7±5.1 years in 1990-2000 to 21.9±9.5 years in 2011-2020 (p-trend=0.025), but there was no significant change in UC (p-trend=0.177). The male-to-female ratio showed a tendency to increase from 0.7 to 1.5 in UC (p-trend=0.002) over 30 years. The UC/CD ratio gradually decreased from 6.4 in 1991-2000, 2.6 in 2001-2010, and 2.5 in 2011-2020. In CD, the colonic phenotype gradually decreased with the recent period (35.7%, 26.2%, and 15.2%, respectively; p<0.01), but there was no difference in disease behavior (p=0.482). At the time of diagnosis, 35.8% of CD patients had a history of perianal abscess/fistula. In UC, there was no change in disease extent according to the periods, and the overall proctitis, left-sided, and pancolitis were 46.2%, 30.2%, and 23.6%, respectively. For the severity of UC, mild disease gradually increased; by 34.4% in 1991-2000, 47.0% in 2001-2010, and 60.1% in 2011-2020, respectively (p<0.001).
Conclusion
The incidence and prevalence of IBD in Korea have continued to increase over the past three decades. Age, male-to-female ratio, phenotype, and severity at the time of diagnosis of IBD in Korea are constantly changing.