Shomron Ben-Horin © ECCO

Michael Scharl © ECCO

Fat in IBD – Much more than an innocent bystander 

Within the framework of the 6^th SciCom Workshop, the role of fat and lipids in IBD pathogenesis was highlighted. Six highly interesting talks shed light on the fact that fat is much more than an innocent bystander in IBD.

Sandra Bohn Thomsen  © Sandra Bohn Thomsen

Evolution after anti-TNF discontinuation in patients with Inflammatory Bowel Disease: A multicentre long-term follow-up study

Casanova MJ, Chaparro M, García-Sánchez V, Nantes O, Leo E, Rojas-Feria M, et al.
Am J Gastroenterol. 2017;112:120–31

Kapil Sahnan  © Kapil Sahnan

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: A randomised controlled, open-label, multicentre trial 

Ponsioen CY, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Bossuyt PMM, Hart A, et al. 
Lancet Gastroenterol Hepatol. 2017;2:785–92. 

Bobby Zhao Sheng Lo © Bobby Zhao Sheng Lo

Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: A multicentre inception cohort study

Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, et al.
Lancet. 2017;389:1710–8.

Dominik Bettenworth  © ECCO

Dear Y-ECCO Friends,

A warm welcome to the Y-ECCO Literature Review section, where you will find a summary and discussion of cutting-edge clinical trials as well as basic science studies in the field of IBD. 

If you are a Y-ECCO Member and you are looking for an opportunity to get actively involved in ECCO and gain some visibility, contribute your article to the Y-ECCO Literature Review corner, together with a short self-description and your picture.

Nuha Yassin  ©  ECCO

Dear Y-ECCO Friends,

We are revisiting the multidisciplinary IBD team. Today, I am delighted to be joined by Palle Bager, an IBD nurse specialist and the current N-ECCO Chair.

Please contact me for any interview suggestions for the Y-ECCO Interview Corner.

Nuha Yassin
Y-ECCO Interview Corner Coordinator

Isabelle Cleynen  ©  ECCO

Dear Y-ECCO Friends,

This will be the last time that I address you as Y-ECCO Chair. At the next ECCO Congress (2018, Vienna), I shall be stepping down and it is with great pleasure that I will then hand over the position of Chair to Nuha Yassin (UK), who has been serving on the Committee for three years. There will also be a new member joining the Committee, for which the selection process has been completed. We received seven excellent applications, and would like to encourage those who were not selected this time to re-apply in coming years.

Miranda Lomer  ©  ECCO

At least a third of patients with inactive IBD have coexisting functional bowel symptoms (e.g.  abdominal pain, bloating, increased flatulence, diarrhoea and/or constipation) and these symptoms may be mistaken for active IBD. Patients may also experience increased anxiety/depression and reduced quality of life. Objective markers of disease activity (histological and inflammatory markers, e.g. faecal calprotectin, C-reactive protein), in conjunction with assessment of clinical symptoms, help to distinguish between functional bowel symptoms and active IBD. Identification of functional bowel symptoms in inactive IBD is important to avoid unnecessary and potentially harmful treatment strategies; on the other hand, active disease should be excluded before establishing that symptoms are functional in nature.

Vincenzo Villanacci  ©  ECCO

The Inflammatory Bowel Diseases (IBD) Crohn’s Disease (CD) and Ulcerative Colitis (UC) are characterised by flares and remission, reflecting the pathological status of the inflamed intestinal tract. For decades, the treatment goal for IBD was the achievement of clinical response or remission. More recently, however, the normalisation of laboratory parameters and intestinal mucosa, termed mucosal healing (MH), has been considered a major target to prevent extra-intestinal complications and achieve sustained clinical remission. 

Richard Russell  ©  ECCO

The revision of the Paediatric UC Guideline for children has been carried out jointly by the ESPGHAN Porto IBD group and ECCO. This revised guideline has updated the previous separate guidelines on Acute Severe UC and Ambulatory UC [1,2] and combined them into one document. The guideline was developed on the basis of an intensive literature search and careful evidence grading; the Oxford levels of evidence were used for the latter purpose after it became clear that the guideline was being developed too soon for the use of GRADE methodology. A summary of all the evidence assimilated during the guideline development will be published as supplementary tables so that others can benefit from the intensive search without having to redo the work.