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04October2018

ECCO Fellowship Study Synopsis: Mathieu Uzzan

Mathieu Uzzan, ECCO Fellow 2018

Deciphering the gut-specific B cell response in Inflammatory Bowel Disease (IBD)  

 

03 SciCom 6a MASTER Mathieu UzzanMathieu Uzzan
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Mathieu Uzzan

Aim of the research

Given that there is a large complement of mucosal B cells that plays a pivotal role in the regulation of the microbiome and in mucosal homeostasis, it is likely that they play an important but yet understudied role in the pathogenesis of IBD. Therefore, we hypothesize that mucosal inflammation as seen in IBD will induce a B cell response with homeostatic and perhaps pathogenic properties.

Posted in ECCO News, SciCom, Committee News, Fellowships & Grants Synopsis Reports, Volume 13, Issue 3

04October2018

ECCO Fellowship Study Synopsis: Federica Branchi

Federica Branchi, ECCO Fellow 2018

Investigation of the role of Par4-associated cell polarity and associated barrier defects in Inflammatory Bowel Diseases  

 

03 SciCom 1a MASTER Federica Branchi fotoFederica Branchi
© 
Federica Branchi

Aim of the research

In Inflammatory Bowel Diseases (IBD), epithelial barrier defects occur as a consequence of chronic inflammation. Recent research has suggested that cell polarity alterations may be upstream of barrier defects and additionally play a role in IBD-associated carcinogenesis (colitis-associated and small intestinal carcinoma). Par4 is a gene encoding a protein crucial in the development of cell polarity. LKB1, its human homologue, is mutated in Peutz-Jeghers syndrome (PJS), a genetic condition characterised by a higher risk of epithelial cancers. Considering the pivotal role of Par4/LKB1 in the development of epithelial cell polarity, this project aims to assess its involvement in IBD-associated barrier defects and carcinogenesis.

Posted in ECCO News, SciCom, Committee News, Fellowships & Grants Synopsis Reports, Volume 13, Issue 3

08June2018

Y-ECCO Literature Review: Viktor Domislović

Viktor Domislović

13 3 ViktorViktor Domislović 
© 
Viktor Domislović

Cumulative burden of inflammation predicts colorectal neoplasia risk in Ulcerative Colitis: A large single-centre study

Choi CR, Al Bakir I, Ding NJ, Lee GH, Askari A, Warusavitarne J, Moorghen M, Humphries A, Ignjatovic-Wilson A, Thomas-Gibson S, Saunders BP, Rutter MD, Graham TA, Hart AL
Gut. 2017 Nov 17. pii: gutjnl-2017-314190. doi: 10.1136/gutjnl-2017-314190.

Posted in ECCO News, Y-ECCO Literature Reviews, Committee News, Y-ECCO, Volume 13, Issue 2

08June2018

Y-ECCO Literature Review: Valentina Petito

Valentina Petito

13 4 V.Petito
Valentina Petito
© Valentina Petito

Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in Inflammatory Bowel Disease

Häsler R, Sheibani-Tezerji R, Sinha A, Barann M, Rehman A, Esser D, Aden K, Knecht C, Brandt B, Nikolaus S, Schäuble S, Kaleta C, Franke A, Fretter C, Müller W, Hütt MT, Krawczak M, Schreiber S, Rosenstiel P
Gut. 2017;66:2087–2097. doi:10.1136/gutjnl-2016-311651

Posted in ECCO News, Y-ECCO Literature Reviews, Committee News, Y-ECCO, Volume 13, Issue 2

08June2018

Y-ECCO Interview corner: Jane Andrews

Nuha Yassin, Y-ECCO Chair

Nuha Yassin v3
Nuha Yassin © ECCO

With the Y-ECCO Interview corner, we travel the world and share the thoughts of some of the most inspirational IBD leaders. Today we travel to Australia in order to share the IBD journey of a very successful and inspirational IBD leader, Professor Jane Andrews, who is head of the IBD service and Education in the Department of Gastroenterology and Hepatology at The Royal Adelaide Hospital in Australia and a clinical professor at the School of Medicine, University of Adelaide.

 

 

Posted in ECCO News, Committee News, Y-ECCO, Volume 13, Issue 2

08June2018

Y-ECCO Members’ Address

Nuha Yassin, Y-ECCO Chair

Nuha Yassin v3
Nuha Yassin © ECCO

Dear Y-ECCO Friends,

Greetings fellow Y-ECCOs. I hope you are all enjoying some warmth after the prolonged winter. The Young ECCO Committee (Y-ECCO) has been using the cold winter time well, wrapped up indoors and brewing up a couple of brand new hot beverages for you as we continue to strive to provide Y-ECCO Members with the best possible offers.

Posted in ECCO News, Committee News, Y-ECCO, Volume 13, Issue 2

08June2018

Serrated lesions in Inflammatory Bowel Disease

Magali Svrcek, H-ECCO Member

Magali Svrcek
Magali Svrcek
© ECCO

In addition to the “classical” pathway of colorectal carcinogenesis, involving development of cancer from an adenomatous precursor lesion, an alternative pathway, the serrated pathway, is now recognised to exist, and it is estimated that approximately 30% of colorectal cancers (CRC) arise via this alternative pathway [1]. In the last WHO classification, serrated polyps were classified as (i) hyperplastic polyps (HP), (ii) sessile serrated adenoma/polyps (SSA/P), with or without dysplasia, and (iii) traditional serrated adenomas (TSA). The possibility of a serrated pathway has also been suggested in colorectal carcinoma complicating Inflammatory Bowel Disease (IBD) [2–4]. Little is known concerning immunohistochemical and molecular features of serrated lesions in IBD: Data are limited to small series of patients or case reports and findings are controversial due to the rarity of the cases. However, the clinical, pathological and biological characteristics of serrated polyps in patients with IBD do seem to resemble those of their sporadic counterparts.

Posted in ECCO News, Committee News, H-ECCO, Volume 13, Issue 2

08June2018

Challenges in using new drugs in children

Lissy de Ridder, P-ECCO Member

Lissy de Ridder
Lissy de Ridder
© ECCO

Paediatric Inflammatory Bowel Disease (IBD) accounts for 10%15% of all incident cases of IBD, while the incidence in children under 10 years old is rising most rapidly [1, 2]. Children and adolescents present with a more severe phenotype of disease and have both higher and unique risks (e.g. fistulising disease, growth failure, pubertal delay) and a longer disease duration, given that IBD is a lifelong disease. 

Posted in ECCO News, Committee News, P-ECCO, Volume 13, Issue 2

08June2018

New members of the S-ECCO Committee

Yves Panis, S-ECCO Chair

Yves Panis
Yves Panis © ECCO

As Chair of the S-ECCO Committee, it is my pleasure to introduce two newly elected members for 2018: Christianne Buskens and Hagit Tulchinsky. Thus, as of today, the members of the S-ECCO Committee are: Antonino Spinelli (Milan, Italy; member until March 2019), Yves Panis (Clichy, France; Chair until February 2020), Michel Adamina (Winterthur, Switzerland; member until February 2020) and Christianne Buskens and Hagit Tulchinsky. Both Christianne and Hagit will stay for 3 years, until February 2021.

Posted in ECCO News, Committee News, S-ECCO, Volume 13, Issue 2

08June2018

Update on elimination diets

Rotem Sigall-Boneh, D-ECCO Chair

Rotem Sigall Boneh
Rotem Sigall-Boneh
© ECCO

In recent years, there has been increasing evidence that diet has an important role in Inflammatory Bowel Diseases and their management, from the pathogenesis of disease through to treatment and supportive therapy. Exclusive enteral nutrition (EEN) is a well-established dietary therapy that leads to induction of remission and also is associated with mucosal healing in patients with Crohn’s Disease (CD), especially in children. However, adherence to this therapy is low and it is difficult to maintain EEN for a long period. The mechanism by which EEN works is still elusive but several possibilities have been suggested. Accordingly, many groups have sought different dietary strategies to treat patients with CD or UC with several goals: Induction of remission, maintenance of remission and management of gastrointestinal symptoms.

Posted in ECCO News, Committee News, D-ECCO, Volume 13, Issue 2