Examining a novel sulphide-reducing diet As Therapy in Ulcerative Colitis (EAT-UC trial)

Robert V. Bryant © Robert V. Bryant

Background & aim of research

It is currently unknown whether diet influences inflammation in Ulcerative Colitis (UC). Observational and experimental data suggest that modulating sulphide within the luminal environment may have therapeutic potential for UC. The aim of this trial is therefore to determine whether a sulphide-reducing diet, designed to attenuate excess microbial production of potentially noxious gases in the colon, can induce remission in UC.

Comparative accuracy of TransPerineal UltraSound (TPUS) versus Magnetic Resonance Imaging (MRI) for the assessment of perianal fistulae in patients with Crohn’s Disease: a prospective observational longitudinal cohort study

Ferdinando D’Amico © Ferdinando D’Amico

Background & aim of research

Magnetic resonance imaging (MRI) is the first-line imaging modality for monitoring of perianal disease in patients with Crohn’s Disease (CD). However, its use depends on local availability, costs and expertise. Few studies are available on the role of transperineal ultrasound (TPUS). Performing MRI alone in all patients would impose a substantial expense on the health service and would represent a limitation for the many patients who cannot tolerate the procedure (e.g. owing to claustrophobia). For this reason, we urgently need a painless, non-invasive, cost-effective and widely available modality to assess perianal disease and predict disease outcomes. In this observational prospective study, we investigate the accuracy of TPUS versus pelvic MRI in the diagnosis and monitoring of medical and surgical treatment of perianal fistulae in CD patients.

The Educational Programme of the 18^th Congress of ECCO starts prior to the official start of the ECCO Congress and courses take place from March, 1-3, 2023. These activities target ECCO’s different interest groups including young gastroenterologists, surgeons, paediatricians, pathologists, IBD Nurses, dietitians, allied health professionals and scientists.

An overview of these activities can be found below. Please note that courses/workshops may run concurrently. As these educational activities have a limited capacity, we encourage you to register at your earliest convenience. Please note the Educational activities take place only onsite in Copenhagen.

The Scientific Programme of the 18^th Congress of ECCO provides attendees the unique opportunity to learn from the world’s leading specialists in the field of Inflammatory Bowel Diseases. Held from Thursday to Saturday, March, 2-4, 2023, the Scientific Programme is structured around basic science, translational medicine and clinical sessions. Additionally, it includes oral presentations of the 40 best abstracts of the Congress. The focus of all sessions is clinical practice founded on science with practical take home messages and, as every year, the congress registration fee includes access to all scientific sessions.

The Scientific Programme will be live transmitted at the time mentioned in the programme (CET). On-demand videos will be available to registered delegates until June 4, 2023.

ECCO’23 Theme: Sequencing in IBD

We look forward to welcoming you at the 18^th Congress of ECCO in Copenhagen!

Laurent Peyrin-Biroulet © ECCO

Dear ECCO Friends,

Research and education are priorities in the ECCO Community. Autumn is a great time for exciting new ECCO events and is the perfect time to start planning your attendance at the ECCO’23 Congress in Copenhagen – where we finally meet again in person. After two years of online Congress meetings, ECCO’23 will be hopefully again face to face, providing great opportunities for networking with ‘old’ friends and establishing new links and collaborations.

I. Catalán-Serra © I. Catalán-Serra

Dear ECCO friends and family,

It is our pleasure to introduce our conversation with the National Representative of Belgium at ECCO, Triana Lobatón.

Triana is originally from Spain, but is currently based in Gent. In this wide-range conversation, we cover different areas including an introduction to IBD care in Belgium and BIRD, the experience of living and working in a different country, research opportunities, the future of ECCO and IBD care in Europe and much more!

We hope you enjoy it!

Nuha Yassin © ECCO

Dear ECCO friends and family,

We hope that you’ve been enjoying the glorious weather and catching up with your families and loved ones as we try to make up for some lost time. We are delighted to welcome new members to the ECCO family and would like to utilise the interview space to get to know them better. This interview is an exciting speed-date with Professor Amy Lightner, who has been a long-standing friend of ECCO and has recently joined the S-ECCO committee. Prof Lightner is a professor of colorectal surgery, inflammation and immunity and the director of the centre of regenerative medicine and surgery. She’s based at the Cleveland Clinic in Ohio. We hope you enjoy getting to know her through this interview. 

Best Wishes,

Nuha Yassin

Consultant Colorectal Surgeon

ECCO News Associate Editor

Robin Dart © Robin Dart

Y-ECCO Interview Corner gives us the opportunity to gain insights into members of the IBD Community, what they do and how they got to where they are. For this edition, I caught up with Dr. Karen Edelblum , a scientist who has a unique and important perspective.

Karen Edelblum combines cell biology and mucosal immunology, with some stunning time-lapse microscopy. She aims to understand how we might harness immune–epithelial interactions in the treatment of Inflammatory Bowel Disease. Having trained at Vanderbilt University and the University of Chicago, she is now assistant professor at Rutgers New Jersey Medical School. We met (over an internet connection) to get her insights into IBD and the science that will move it on.

Higher vs standard adalimumab induction dosing regimens and two maintenance strategies: Randomized SERENE CD trial results

D‘Haens GR, Sandborn WJ, Loftus Jr EV, et al.

Gastroenterology 2022 Feb 3; doi: 10.1053/j.gastro.2022.01.044. Online ahead of print

Aaron S. Bancil © Aaron S. Bancil

Introduction

Traditionally, treatment of Crohn’s Disease (CD) has focused on symptomatic, clinical and corticosteroid-free remission. However, more recent studies have shown that endoscopic remission is associated with more favourable patient long-term outcomes [1, 2]. It has been hypothesised that more intense treatment regimens may increase the likelihood of endoscopic remission in CD patients. Previous studies (such as that performed by the DIAMOND study group) have indicated that adalimumab trough levels are higher in CD patients who achieve an endoscopic response and mucosal healing at weeks 26 and 52 [3]. Further to that, the personalised anti-TNF therapy in Crohn's Disease study (PANTS) demonstrated that low drug levels were predictive of anti-tumour necrosis factor (anti-TNF) treatment failure [4].

Various methods of dose optimisation have been postulated, such as higher induction doses, therapeutic drug monitoring (TDM) to guide dose optimisation during the maintenance phase or a clinically adjusted (CA) dose optimisation strategy.

Decreased risk of treatment failure with vedolizumab and thiopurines combined compared with vedolizumab monotherapy in Crohn’s disease

Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C Kim

Gut 2022 Apr 6; doi: 10.1136/gutjnl-2022-327002. Online ahead of print

Charles Miller © Charles Miller

Introduction

Vedolizumab (VDZ) was the first biologic to be approved for Ulcerative Colitis (UC) and Crohn’s Disease (CD) after the age of anti-tumour necrosis factor antagonists (anti-TNF). The role of thiopurines in combination with anti-TNFs in the management of IBD is well recognised. However, the role for combination of VDZ with thiopurines is uncertain [1, 2]. This study aimed to investigate the comparative effectiveness of VDZ in combination with a thiopurine versus VDZ monotherapy in the management of both UC and CD.

Charlotte Hedin © ECCO

Dear Y-ECCO Friends,

We are living through challenging times; the pandemic is evolving but is not yet over and conflict in Europe occupies all our minds. Many training programmes and research projects have had to be delayed or adapted over the last two years, but now that restrictions are less onerous much of our clinical and research work is back on track. I therefore hope that you all got your abstracts in to the UEG before the deadline at the end of April. Bear in mind also that the ECCO'23 abstract submission is open. We are looking forward to reading your contributions and selecting the best abstracts for the Y-ECCO Awards and the Basic Science Workshop.