Randomised clinical trial: high‐dose oral thiamine versus placebo for chronic fatigue in patients with quiescent inflammatory bowel disease (TARIF study)

Bager P, Hvas CL, Rud CL1, Dahlerup JF

Aliment Pharmacol Ther 2021;53(1):79–86.

Eathar Shakweh © Eathar Shakweh

Introduction

Fatigue is a common yet poorly understood manifestation of Inflammatory Bowel Disease (IBD) and can occur independently of disease activity. A prospective cohort study of 326 IBD patients initiating biologic therapy (with infliximab, vedolizumab or ustekinumab) demonstrated fatigue was prevalent at baseline (63%)¹. Whilst fewer patients reported fatigue with treatment (70% at week 14, 61% at week 30 and 61% at week 54), a third continued to experience fatigue despite achieving clinical remission. This is supported by other studies, where fatigue prevalence in quiescent disease was as high as 36% in Ulcerative Colitis (UC) and 41% in Crohn’s disease (CD)².

A phase 1b safety study of SER-287, a spore-based microbiome therapeutic, for active mild to moderate ulcerative colitis

Henn M, O’Brien E, Diao L, et al.

Gastroenterology 2021;160(1):115–27.

Djuna de Jong © Djuna de Jong

Introduction

In the last decade, research on the human gut microbiome and its influence on health and disease has taken flight. This has strengthened the belief that the underlying pathogenesis of Inflammatory Bowel Disease (IBD) involves an altered immune response to characteristic shifts in the composition of the gut microbiome.

Johan Burisch © ECCO

Dear Y-ECCO Friends,

After a 2020 that ended up being all about COVID-19, let’s hope that 2021 will be a normal year where we can meet and network again and put COVID behind us. I recently got my first shot of the vaccination, which was a wonderful experience of what science is capable of in times of need. In Denmark we’ve started vaccinating our IBD patients but vaccine scepticism and uncertainties about the evidence is everywhere and we as physicians are needed more than ever to inform our patients.

Although the relationship between IBD and nutrition is of longstanding interest, the attention paid to it has increased dramatically in recent years, with the inclusion of nutritional interventions in ECCO Guidelines on both paediatric and adult Crohn’s Disease (and of course many other IBD guidelines), bespoke publications such as the ECCO perioperative dietary therapy topical review and a flowering of clinical interest in Crohn’s Disease-specific diets.

This clinical interest in nutritional issues in IBD is also reflected in the exceptional interest in a December 2020 educational article in the UEG Journal “Mistakes in…” series, namely “Mistakes in nutrition in IBD and how to avoid them” by the ECCO Members Joe Meredith, Kostas Gerasimidis and Richard Russell (ueg.eu/a/268). Basic and translational scientific studies of the pathogenesis of IBD have increasingly evaluated the role of nutrition and particularly its interaction with the microbiome.

Michel Adamina © ECCO

For the past year the COVID-19 pandemic has raged across the world, with wave after wave of the disease. No country has been spared and no end is in sight in the near future. A recent position paper from the ECCO COVID-19 Taskforce presented the ten ‘dos and don’ts’ when caring for IBD patients. S-ECCO Members are involved in the specialised surgical care of IBD patients in many countries and a variety of institutions. Hence, we are offering this opinion piece on the performance of IBD surgery during the pandemic.

Marjo Campmans-Kuijpers © ECCO

Due to COVID-19, the 16^th ECCO Congress originally planned for February 2021 in Berlin was postponed to July 7–10 in the Bella Center in Copenhagen. However, in view of the current COVID-19 situation, the ECCO Governing Board had to switch to ECCO’ 21 Virtual Congress. It’s a pity we cannot meet each other live, but holding the Congress online may increase the opportunity for more people to attend both the Congress itself and our 6^th D-ECCO Workshop.

Susanna Jäghult  © ECCO

Following the summary of the ECCO'21 Educational Programme N-ECCO have prepared for you, we are very excited and looking already ahead to the ECCO'22 Congress.

After a year during which most of the focus has been on COVID-19 and most of our meetings have been digital, we can finally see some light at the end of the tunnel and look forward to meeting face to face again. Unfortunately, we need to wait a bit longer and the ECCO Congress will this year be a virtual meeting. We have arranged a lot of very interesting sessions and I hope you all will sign up. But we have also been very active in planning for the ECCO Congress in 2022, which, I am very proud and happy to say, will be held in Stockholm, my home town. I hope to see you all there!

Hannah Gordon  © ECCO

On Sunday October 11, 2020, all participants of the ECCO Guidelines on Prevention and Management of Infection met with the aim of reaching a consensus on each statement of the guideline. This guideline provides evidence-based insights into the prevention, diagnosis and management of infection in Inflammatory Bowel Disease. The project is led by Torsten Kucharzik and Stephan Vavricka, with 25 authors from 15 different countries. This is ECCO’s third guideline on infection in IBD; the first guideline on opportunistic infection was published in 2009, and updated in 2014.

Henit Yanai  © ECCO

“I’m not a fellow anymore but I would love to have the opportunity to be part of such a course!” This is a quote from a colleague who works in a private practice that I heard on the bus on the way back to Copenhagen airport after ECCO 2019. Thanks to this remark we embarked on this endeavour to hold the 1^st ECCO Postgraduate Course in IBD.  

Pascal Juillerat  © ECCO

Dear ECCO Members,

I hope you and your families are well and you are looking forward to spending the Christmas holidays together, as far as this is possible. In case you missed or would like to re-watch some of the content from the ECCO’21 Virtual Congress that took place last summer – we kindly ask you to visit our e-Library, where all of the recordings can be found.