Induction of circadian microbial function in chronic intestinal inflammation

Silke Kiessling © Silke Kiessling

Background & aim of research

Impaired clock gene expression has been observed in biopsies from patients with Inflammatory Bowel Disease (IBD). Disruption of circadian rhythms, which occurs in shift workers, has been linked to an increased risk of gastrointestinal diseases, including IBD. The intestinal clock balances gastrointestinal homeostasis by regulating the microbiome. We aimed to characterise intestinal immune functions in mice lacking the intestinal clock and in IBD-relevant mouse models under different feeding conditions in order to assess the functional impact of the intestinal clock in the development of gastrointestinal inflammation.

Investigating the genetics of IBD multiplex families

Ho-Su Lee © Ho-Su Lee

Background & aim of research

This research aimed to investigate the genetic architecture of Inflammatory Bowel Disease (IBD) multiplex families (including at least three affected first-degree relatives), and to identify the underlying genetic factors that contribute to the familial aggregation of IBD.

Role of DNA methYlation and geNe expression alterations in development of eArly-onset priMary sclerosIng cholangitis in ulCerative colitis – DYNAMIC

Sudipto Das © Sudipto Das

Background & aim of research

Primary Sclerosing Cholangitis (PSC) is a progressive choleostatic disease and up to 80% of patients also have Ulcerative Colitis (PSC-UC). This presents a clinical challenge owing to the diagnostic difficulty and the increased risk for development of cancer. The aim of this study was to identify the transcriptomic and epigenetic alterations regulating the phenotype of this disease.

The role of autophagy in limiting IBD-associated AIEC-induced intestinal inflammation

Shai Bel © Shai Bel

Background & aim of research

While the aetiology underlying the development of Inflammatory Bowel Diseases (IBD) is unclear, evidence points to an interaction between host genetics, such as mutations in autophagy genes, and environmental factors, such as bacterial infections. Multiple studies have identified an adherent-invasive Escherichia coli pathotype (AIEC) only in patients with IBD. It is thought that AIEC exploits the intestinal inflammation in patients with IBD to attach to intestinal epithelial cells, intensifying the pre-existing inflammation. Studies in vitro have shown that functional autophagy is crucial to eliminate AIEC infection. Here, we aimed to identify how autophagy protects the host from AIEC-associated pathologies in vivo.

Marc Ferrante © ECCO

Yves Panis © ECCO

Pauline Rivière © Pauline Rivière

For two years, a group of 25 IBD specialists, including gastroenterologists, surgeons and scientists, have been working to build a research framework for postoperative recurrence (POR) in patients with Crohn’s Disease. Even though more biological therapies are now available, ileocaecal resection is still a frequent event and POR management remains a challenge for both patients and IBD specialists.

The Educational Programme of the 19^th Congress of ECCO starts prior to the official start of the ECCO Congress and courses take place from February 21-24, 2024. These activities target ECCO’s different interest groups including young gastroenterologists, surgeons, paediatricians, pathologists, IBD Nurses, dietitians, allied health professionals and scientists.

Britta Siegmund © ECCO

Dear ECCO Friends,

It is autumn already, many us have attended the UEG Week in Copenhagen and we are already preparing for the next ECCO Congress 2024 in Stockholm!

The theme of the Stockholm Congress is “Crossing Borders in IBD”, which underlines the global community that ECCO embraces, working together to improve patient care and quality of life worldwide. In view of the last few weeks, we would like to emphasise that ECCO stands for peaceful coexistence and sympathy for all the innocent people who are suffering. We as ECCO demand the immediate release of all hostages. We sincerely hope that the situation will calm down soon and that we will be able to see each other in Stockholm!

Dear ECCO Friends and Family,

In this new episode of our podcast “Meet the JCC Author”, it is my pleasure to introduce Philip Harvey from the Royal Wolverhamptom NHS Hospital, UK.

He talks about his paper recently published in JCC: “Venous Thromboembolism following discharge from Hospital in Patients Admitted for Inflammatory Bowel Disease”.

We hope you enjoy it and do not forget to spread the word about our new podcast to your friends and colleagues!

Best Wishes,

Brigida Barberio

ECCO News Associate Editor

Alessandro Armuzzi © ECCO

Gionata, why did you decide to be a gastroenterologist, and then an IBDologist?

I decided to be a gastroenterologist and an IBDologist at the same time. It happened during my third year of medical school. During my pathology class, I loved to learn about mechanisms of inflammation, and I realised my favourite topic was intestinal inflammation. At the same time, I was sensitive to IBD, since I have got seven cases of IBD in my family; therefore I decided to start my career in this specific field.

Robin Dart © ECCO

Iris Dotan is a gastroenterologist and mucosal immunologist based at Rabin Medical Center, Israel. She is chair of the International Organization for the Study of Inflammatory Bowel Disease (IOIBD) and is well known to ECCO Members through her previous membership of SciCom, her speeches at ECCO Congress and her permanent presence on the Hearts and Minds dancefloor. During a break at the ECCO Congress in Copenhagen, I sat down with Iris to discuss her career, how mentorship has been important to her and, for anyone who has been on a Zoom call with her in the last 3 years, the origins of the beautiful painting she is usually seen sitting in front of.