ECCO'24 Abstracts

ECCO'24 Abstracts on the JCC Website

ECCO'24 Abstract Book PDF Version

ECCO'24 Abstracts COI Disclosure

Poster presentations: Basic Science 2021

P001 Succinate, a gut microbiota-derived metabolite, modulates the inflammatory status of the creeping fat in Crohn’s disease.

P002 Methodological development of single-cell phenotyping and spatial analysis of intestinal leukocyte, stromal and epithelial cell populations in inflammatory bowel disease formalin fixed paraffin embedded tissue by Hyperion imaging mass cytometry

P003 HDAC7 Controls Differentiation and Regeneration in the Intestinal Epithelium

P004 Critical paralog proteins has a cell-type specific rewiring role in Ulcerative Colitis associated signalling processes

P005 Cytokine mediated intercellular communication in inflammatory bowel disease

P006 Host-genetics, dysbiosis, and clinical history explains fecal metabolic alterations in patients with Inflammatory Bowel Disease

P007 Identification and characterisation of intestine-derived circulating resident memory T cells (ex-Trm) in health and Inflammatory Bowel Disease

P008 Store-operated calcium entry controls immune cell function and activation in Inflammatory Bowel Disease

P009 Disease classifier and microbial dysbiosis index tools cross-predict various pathogenic conditions due to general microbial signal

P010 GSDMB-mediated pyroptosis exacerbates intestinal inflammation by destroying intestinal epithelium in Crohn’s disease

P011 Serum adhesion G protein coupled receptor levels are associated with disease activity in pediatric patients with Crohn’s disease

P012 Low frequencies of circulating inhibitory TIGIT+CD38+ effector T cells identify an immunologically distinct subgroup of pediatric patients with severe Crohn's disease

P013 Potential Role of Epithelial Protein Disulphide Isomerases in Crohn’s Disease Fibrosis

P014 Untargeted serum metabolome in longitudinal Crohn's Disease (CD) cohort enrolled during remission shows strong individualized signature and CD-associated signals that are maintained also in patients who normalized their fecal calprotectin

P015 Differential expression in colitis-associated cancer compared to Crohn´s disease and ulcerative colitis

P016 SZN-1326, a Wnt signal activator, is more efficacious than cyclosporine A in an acute DSS model

P017 Small bowel transcriptomics define similarities and divergent pathways between Crohn, environmental enteric dysfunction (EED), and celiac diseases, implicating role for the microbiome in the pathogenesis

P018 Myeloid diversity in inflammatory bowel disease revealed by single-cell transcriptomics

P019 Differential effects of first-line IFX and conventional treatment on inflammatory serum proteins of paediatric moderate- to-severe Crohn’s disease patients.

P020 Mapping the changing intercellular communication and its downstream effect in Ulcerative Colitis

P021 Circulating inflammatory protein and cellular profiles at time of diagnosis classify inflammatory bowel disease patients according to their underlying immune response and clinical disease course

P022 Pathologic involvement of the farnesoid X receptor/fibroblast growth factor 19 axis to the Crohn’s disease early postsurgical recurrence.

P023 SZN-1326, a Wnt agonist, improved epithelial healing and ameliorated colitis in a chronic DSS model, in stark contrast to anti-TNF and anti-IL-12/23p40 antibodies

P024 Development of a treatment for short bowel syndrome using small intestinal organoids

P025 Identification and validation of predictors for tofacitinib through supervised and unbiased approaches in Inflammatory Bowel Disease

P026 Microbial Diversity is affected by Cognitive Behavioral and Mindfulness-Based Stress Reduction and accompanied by an Inflammatory Response in Patients with Crohn’s Disease

P027 Epithelial cells of patients with ulcerative colitis do not show an increased sensitivity after microbiota stimulation compared to non-IBD controls

P028 The Apa I polymorphism in the Vitamin D receptor gene is associated with a stricturing behaviour in Crohn´s disease patients

P029 Activation of FXR restores expression of genes dysregulated in human IBD and suppresses TNFa and IL-6 signaling pathways in adoptive transfer colitis model

P030 SUCNR1 mediates inflammasome activation: Relevance in Ulcerative Colitis

P031 Class A1 scavenger receptor mediates macrophage polarization and apoptotic progression in a murine dextran sulfate sodium-induced colitis

P032 MiR-511 deficiency aggravates T cell transfer colitis in mice

P033 Dendritic cells from patients with active IBD imprint pro-inflammatory α4β7+CLA+ T cells with potential for gut and skin homing

P034 Human primary 2D culture as a tool to explore JAK1 pathway inhibition in the intestinal epithelium using siRNA technology

P035 Potential biomarkers for diagnosis through proteomics, in patients with Inflammatory Bowel Disease

P036 MicroRNA composition of colon crypt-top and crypt-bottom epithelial cells in Ulcerative Colitis

P037 Nonclinical pharmacokinetics and absorption, distribution, metabolism, and excretion properties of MORF-057 support its clinical development as an oral selective α4β7 integrin inhibitor

P038 Microbial regulation of T-cell fate towards regulatory profiles during T-cell transfer induced colitis

P039 New molecular markers of the development of ulcerative colitis

P040 USP16 regulates p65 activation in macrophages and promotes the inflammatory-carcinoma transformation process in IBD patients

P041 CDKN2B-AS1 (ANRIL) expression is decreased in Inflammatory Bowel Disease epithelia and in Celiac, and its reduction is linked with induced cells proliferation

P042 Diagnostic and prognostic value of soluble adhesion molecules in patients with ulcerative colitis

P043 Succinate receptor (SUCNR1) mediates leukocyte-endothelial cell interactions induced by TNFa

P044 Transcriptome analysis identifies dysregulated pathways and targets for therapy in patients undergoing surgical resection for Crohn’s disease

P045 Oncostatin M induces strong fibrotic and chemokine responses from primary colonic subepithelial myofibroblasts

P046 Disease modelling of Inflammatory Bowel Disease by human colon organoids

P047 The ATG16L1 T300A polymorphism in Crohn's Disease patients leads to abnormal autophagy flux in dendritic cells

P048 Intestinal inflammation and microbiome diversity are conserved more in consecutive pregnancies among women with inflammatory bowel disease compared to healthy controls

P049 Development of human embryonic stem cell-derived intestinal organoids for in vitro studies on intestinal inflammation and fibrosis

P050 Effect of biological treatments (anti-TNFs) in the creeping fat of Crohn’s disease patients

P051 Macrophages as a source of Notch Ligands in Crohn's disease: implications in fibrosis

P052 Comprehensive proteomic profiling of stool from UC and CD patients reveals expected and novel mucosal pathobiology, enabling identification of candidate non-invasive biomarkers to monitor mucosal disease activity

P053 Overabundance of Lactobacillus species in gut microbiota of IBD patients

P054 Modulation of the Gut Microbiota-Farnesoid X Receptor Axis Improves Deoxycholic Acid-induced Intestinal Inflammation in Mice

P055 Brain-Immune Axis Regulation is Responsive to Cognitive Behavioral and Mindfulness-Based Stress Reduction in Crohn’s Disease

P056 Crohn’s Disease associated fibrosis modulates the expression of collagen receptors

P057 CRL4DCAF2 promotes cell proliferation and limits the development of colitis

P058 Proteomic analysis-based discovery of a novel biomarker that differentiates intestinal Behçet’s disease from Crohn’s disease

P059 GB004 drives protective effects on immune cells and epithelial cells using human ex vivo monolayer and co-culture systems

P060 A2B adenosine receptor deficiency ameliorates chronic murine Crohn’s-like-ileitis.

P061 Immune cell infiltrations of myenteric plexus in IBD – characterization and implications

P062 Effects of exposure to steroids on the PredictSURE whole blood prognostic assay in Inflammatory Bowel Disease

P063 The immunological landscape of intestinal fibrosis in Crohn’s Disease.

P064 3-oxo-C12:2, a Quorum Sensing molecule from the gut, exerts anti-inflammatory effects through a bitter taste receptor

P065 Conservation of breast milk cytokine profiles in consecutive pregnancies of women with inflammatory bowel disease

P066 Exploration of critical molecules for optimizing treatment by analyzing　inflammatory cytokines in the intestinal mucosa of patients with Inflammatory Bowel Disease

P067 The effect of a probiotic mix on mucosal healing and fibrotic responses in healthy colonic subepithelial myofibroblasts.

P068 The combination of JAK1 and TPL2 or IRAK4 inhibitors is more effective than single agents in reducing TLR-mediated cytokine responses in human monocyte populations

P069 Artificial intelligence (AI)-filtered Videos for Accelerated Scoring of Colonoscopy Videos in Ulcerative Colitis Clinical Trials

P070 Efficacy of a novel non-covalent oral small molecule Nrf2 activator in a rat model of Inflammatory Bowel Disease

P071 Crohn’s Disease is associated with elevated levels of the pro-inflammatory CXCR3 ligands (CXCL9, 10 and 11) with an associated reduction in Paneth cell derived antimicrobial peptides in ex-vivo ileal biopsies

P072 The involvement of extracellular Nicotinamide Phosphoribosyltransferase (eNAMPT) and Nicotinate Phosphoribosyltransferase (eNAPRT) in inflammatory bowel disease

P073 An increased autophagy and decreased apoptosis is detected in intestinal fibroblasts from Crohn’s Disease patients

P074 Crohn’s disease clinical data standards: Adoption and implementation to promote data sharing and reuse.

P075 Multidimensional assessment of interoceptive abilities, emotion processing and the role of early life stress in Inflammatory Bowel Disease

P076 The endocannabinoid system in the intestinal biopsies of children with Inflammatory Bowel Disease

P077 What matters to Ulcerative Colitis patients when they make treatment decisions? A systematic review

P078 Proteomics and Lipidomics Analysis Revealed Alterations of Complement Activation and Lipid Metabolism in peripheral blood mononuclear cells of Inflammatory Bowel Disease Patients

P079 Valproic acid increases MiR449a expression in intestinal mucosa from patients with inflammatory bowel disease

P080 Burden of Disease and Cost of Illness of Inflammatory Bowel Diseases in Portugal

P081 Resolvin D2 attenuates colonic inflammation of Crohn’s disease patients

P082 Assessment of anti-inflammatory effect of high acetate administration in UC patient-derived epithelial monolayer cultures

P083 High prevalence of ulcerative appendicitis in UC patients without colonic disease activity

P084 C-Reactive Protein Correlates with Tumor Necrosis Factor-α in Ulcerative Colitis

P085 Expression profiling of Wnt pathway genes in colon biopsies of patients with Ulcerative Colitis

P086 Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon immune dysregulation and intestinal permeability in a stress-induced colonic inflammation

P087 The role of bile acids in mediating fibrosis in inflammatory bowel disease

P088 Neurotuberculosis in a patient with Ulcerative Colitis using adalimumab for a long period in Brazil

P089 IFNγ-macrophages could mediate EMT in Crohn’s disease