Laurent Peyrin-Biroulet © ECCO

Dear ECCO Friends,

Welcome to the last issue of ECCO News for 2022!

In ECCO News Issue 4 our Associate Editors have continued with the second episode of a new interesting series Meet the JCC Authors where Maria Chaparro and Mette Julsgaard are discussing their recent paper in the Journal of Crohn’s and Colitis titled: "Surgery due to Inflammatory Bowel Disease During Pregnancy: Mothers and Offspring Outcomes From an ECCO CONFER Multicentre Case Series [Scar Study]".

Alessandro Armuzzi © Alessandro Armuzzi

Dear colleagues and friends of the IBD Community,

Warm greetings from the ECCO News Team as we start a new year full of hopes and dreams.

Although the pandemic and the measures to combat it have profoundly affected and are still shaping all our lives in a variety of ways, we at ECCO have adapted to recent events and are now trying to return, as far as possible, to normal. In the meantime, the whole ECCO Team has worked and continues to work hard to continue providing high-quality research, education and training opportunities with the aim of disseminating the ‘best’ standard of care for patients affected by Inflammatory Bowel Disease.

The Educational Programme of the 18^th Congress of ECCO starts prior to the official start of the ECCO Congress and courses take place from March 1-4, 2023. These activities target ECCO’s different interest groups including young gastroenterologists, surgeons, paediatricians, pathologists, IBD Nurses, dietitians, allied health professionals and scientists.

An overview of these activities can be found below. Please note that courses/workshops may run concurrently. As these educational activities have a limited capacity, we encourage you to register at your earliest convenience. Please note the all educational activities can only be attended onsite in Copenhagen.

The Scientific Programme of the 18^th Congress of ECCO provides attendees the unique opportunity to learn from the world’s leading specialists in the field of Inflammatory Bowel Diseases. Held from Thursday to Saturday, March 1-4, 2023, the Scientific Programme is structured around basic science, translational medicine and clinical sessions. Additionally, it includes oral presentations of the 40 best abstracts of the Congress. The focus of all sessions is clinical practice founded on science with practical take home messages and, as every year, the congress registration fee includes access to all scientific sessions.

The Scientific Programme will be live transmitted at the time mentioned in the programme (CET). On-demand videos will be available to registered delegates until June 4, 2023.

ECCO’23 Theme: Sequencing in IBD

We look forward to welcoming you at the 18^th Congress of ECCO in Copenhagen!

Fine determination of gut tissue layers' inflammation exploring immune-microbiota signatures: new biomarkers of recurrence in surgical patients with Crohn's disease?

Francesco Giudici © Francesco Giudici

Edda Russo © Edda Russo

Amedeo Amedei © Amedeo Amadei

Aim of the research

Up to 65% of patients with Crohn’s Disease (CD) show disease recurrence after ileocolic resection (ICR). The reasons for this high recurrence rate are still unclear, but the abnormal CD inflammatory process, supported by microbiota dysbiosis, affects all the intestinal wall layers. We explored the mutual interplay of inflammatory and microbial factors involved in CD through a systems-level study (tissue and systemic level), at the time of ICR, evaluating whether these specific factors are associated with CD recurrence.

CCR6 blockade as novel therapeutic strategy against inflammatory bowel disease

Aim of the research

The CCL20/CCR6 axis is recognized as critical in IBD pathogenesis. However, CCR6 blockage has never been tested as therapeutic approach and no small-molecules CCR6 antagonists have been investigated as a potential anti-IBD drug candidates. Starting from our novel CCR6 antagonist (MR120), we aimed at: -designing and synthesizing more potent CCR6 antagonists; -identifying the most efficacious and tolerable anti-chemotactic CCR6 antagonist; -assessing the efficacy of MR120 and of the most promising novel derivative in adoptive transfer colitis (AT).

Jun Miyoshi  © Jun Miyoshi

Although I had to postpone my visit to Städtisches Klinikum Lüneburg due to the global COVID-19 outbreak, I was finally able to participate in intestinal ultrasound (IUS) training there in August to September 2022. I thank everyone involved in providing me with this great opportunity.

Suzanne van Zundert © Suzanne van Zundert

When mild to moderate Crohn’s Disease is diagnosed, various dietary approaches are used as a first-line medical treatment with a view to reducing inflammatory symptoms and achieving remission. It is important that this treatment is properly guided by a (paediatric) gastroenterologist and specialised nutritionist.

Shaji Sebastian © ECCO

Antonino Spinelli © ECCO

It is well known that the outcomes of surgery, and especially of IBD surgery, are not merely dependent on the operative procedure but are influenced by a number of factors before, during and after surgery. The multidisciplinary team involved in the care of IBD patients has the opportunity to optimise patient care and status prior to surgery to ensure optimal outcomes and reduce the risk of complications.

Pascal Juillerat  © ECCO

Dear ECCO Members,

Greetings to you and your families! I am sure you are all looking forward to the holidays and spending some quality time with all your loved ones.

I am excited to announce our revamped e-CCO Learning Platform!

With the new, and completely re-designed website, everything you need is now just one click away. The three main pillars of the e-Learning platform are now front and centre: The IBD Curriculum is here to serve you! It is a complete and comprehensive curriculum which outlines the need-to-know for gastroenterologists in order to develop expertise in the field of IBD. The e-Guide is a practical tool to help you manage IBD patients by visualising the ECCO Guidelines as algorithms based on the main UC and CD ECCO Guidelines. Of course, the guidance given by the ECCO e-Guide is based on evidence and validated processes. The e-Library, is your portal to access our large selection of IBD content! Anything from Congress Presentations, Videos, Podcasts, Tools and Skills, Congress Abstracts and much more!

With the re-designed website, you are now able to access all of the content with your mobile phone or tablet, too.

Susanna Jäghult © ECCO

Marie Andersson © ECCO

The e-CCO Learning Platform is fantastic and a real goldmine! The number of activities is enormous, all of them of high quality. The N-ECCO Committee has started to discuss how this goldmine can best be made available to IBD Nurses around Europe.